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1. (WO2001034113) APPARATUS AND METHOD FOR PREPARING MICROPARTICLES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/034113 International Application No.: PCT/US2000/041842
Publication Date: 17.05.2001 International Filing Date: 03.11.2000
Chapter 2 Demand Filed: 06.06.2001
IPC:
A61K 9/16 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
16
Agglomerates; Granulates; Microbeadlets
Applicants:
ALKERMES CONTROLLED THERAPEUTICS INC. II [US/US]; 64 Sidney Street Cambridge, MA 02139-4136, US
Inventors:
LYONS, Shawn, L.; US
WRIGHT, Steven, G.; US
Agent:
REISTER, Andrea, G. ; Covington & Burling 1201 Pennsylvania Avenue, NW Washington, DC 20004-2401, US
Priority Data:
09/438,65912.11.1999US
Title (EN) APPARATUS AND METHOD FOR PREPARING MICROPARTICLES
(FR) APPAREIL ET PROCEDE DE PREPARATION DE MICROPARTICULES
Abstract:
(EN) Apparatus and method for preparing microparticles. An emulsion is formed by combining two phases in a static mixing assembly (730). The static mixing assembly preferably includes a preblending static mixer (732) and a manifold (734). The emulsion flows out of the static mixing assembly into a quench liquid whereby droplets of the emulsion form microparticles. The residence time of the emulsion in the static mixing assembly is controlled to obtain a predetermined particle size distribution of the resulting microparticles.
(FR) L'invention concerne un appareil et un procédé permettant de préparer des microparticules. Une émulsion est formée par combinaison de deux phases dans un ensemble de mélange statique (730) comprenant de préférence un mélangeur statique (732) de prémélange et un collecteur (734). L'émulsion s'écoule hors de l'ensemble de mélange statique pour pénétrer dans un liquide de trempe dans lequel des gouttelettes de l'émulsion forment des microparticules. Le temps de séjour de l'émulsion dans l'ensemble de mélange statique est commandé de manière à obtenir une répartition granulométrique prédéterminée des microparticules.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)