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1. (WO2001034112) SUSTAINED-RELEASE DRUG FORMULATIONS FOR IMPLANTATION
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/034112 International Application No.: PCT/JP2000/007639
Publication Date: 17.05.2001 International Filing Date: 31.10.2000
Chapter 2 Demand Filed: 08.06.2001
IPC:
A61K 9/00 (2006.01) ,A61K 47/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
02
Inorganic compounds
Applicants:
SANO, Akihiko [JP/JP]; JP (UsOnly)
KAJIHARA, Masako [JP/JP]; JP (UsOnly)
MAEDA, Hiroo [JP/JP]; JP (UsOnly)
SUMITOMO PHARMACEUTICALS COMPANY, LIMITED [JP/JP]; 2-8, Dosho-machi 2-chome, Chuo-ku Osaka-shi, Osaka 541-8510, JP (AllExceptUS)
Inventors:
SANO, Akihiko; JP
KAJIHARA, Masako; JP
MAEDA, Hiroo; JP
Agent:
AOYAMA, Tamotsu ; IMP Building 3-7, Shiromi 1-chome, Chuo-ku Osaka-shi, Osaka 540-0001, JP
Priority Data:
11/31910810.11.1999JP
Title (EN) SUSTAINED-RELEASE DRUG FORMULATIONS FOR IMPLANTATION
(FR) FORMULATIONS DE MEDICAMENTS A LIBERATION PROLONGEE DESTINEE A L'IMPLANTATION
Abstract:
(EN) The present invention relates to a formulation for implantation having a novel constitution, which accomplishes controlled releases of active ingredients. The formulation comprises one of combinations (a), (b) and (c), as well as a carrier comprising a hydrophobic polymer, wherein the particle combination is dispersed into the carrier: (a) particles comprising an active ingredient, particles comprising a carbonate, and particles comprising a substance which is reacted with the carbonate in an aqueous solution to generate carbon dioxide (substance such as an acid); (b) particles comprising an active ingredient and a carbonate, and particles comprising a substance such as an acid; and (c) particles comprising a carbonate, and particles comprising an active ingredient and a substance such as an acid.
(FR) La présente invention concerne une formulation de constitution nouvelle destinée à l'implantation, caractérisée en ce qu'elle libère les principes actifs de façon contrôlée. Ladite formulation comprend l'une des combinaisons (a), (b) et (c) ci-après, ainsi qu'un excipient renfermant un polymère hydrophobe, la combinaison de particules étant dispersée dans l'excipient : (a) particules comprenant un principe actif, particules comprenant un carbonate, et particules comprenant une substance que l'on fait réagit avec le carbonate dans une solution aqueuse pour générer du dioxyde de carbone (substance telle qu'un acide) ; (b) particules comprenant un principe actif et un carbonate, et particules comprenant une substance telle qu'un acide ; et (c) particules comprenant un carbonate, et particules comprenant un principe actif et une substance telle qu'un acide
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)