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1. (WO2001034108) IMPROVED STANNOUS ORAL COMPOSITIONS

Pub. No.:    WO/2001/034108    International Application No.:    PCT/US2000/030809
Publication Date: Fri May 18 01:59:59 CEST 2001 International Filing Date: Sat Nov 11 00:59:59 CET 2000
IPC: A61K 8/19
A61K 8/21
A61K 8/24
A61K 8/365
A61K 8/73
A61K 8/81
A61K 8/90
A61Q 11/00
Applicants: THE PROCTER & GAMBLE COMPANY
Inventors: GLANDORF, William, Michael
BACCA, Lori, Ann
WHITE, Donald, James, Jr.
BUSSCHER, Henk, J.
Title: IMPROVED STANNOUS ORAL COMPOSITIONS
Abstract:
The present invention relates to oral compositions comprising a stannous ion source, a fluoride ion source, and a polymeric mineral surface active agent that binds stannous, said compositions providing adequate therapeutic efficacy with minimal side effects of tooth staining and astringency. The composition simultaneously provides reduction and control of supragingival calculus. The present oral care compositions may be formulated as single phase or dual phase compositions. The present invention also provides a method for effective delivery of stannous-containing compositions with minimal side effects of tooth staining or astringency and with effective tartar control by administering to a subject a stable dentifrice composition comprising a clinically effective amount of stannous fluoride and/or other stannous salts in combination with a fluoride ion source and a polymeric mineral surface active agent, preferably a phosphate- or phosphonate-containing polymer.