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1. (WO2001032906) OLIGOMERS AND OLIGOMERIC SEGMENTS OF ALPHA-HYDROXY CARBOXYLIC ACIDS AND ALPHA-AMINO ACIDS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/032906 International Application No.: PCT/US2000/029897
Publication Date: 10.05.2001 International Filing Date: 30.10.2000
Chapter 2 Demand Filed: 10.05.2001
IPC:
C07K 7/06 (2006.01) ,C12P 21/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
06
having 5 to 11 amino acids
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21
Preparation of peptides or proteins
Applicants:
NOVUS INTERNATIONAL, INC. [US/US]; 530 Maryville Centre Drive St. Louis, MO 63141, US
Inventors:
LORBERT, Stephen, J.; US
SCHASTEEN, Charles, S.; US
NAM, Paul, K., S.; US
FORCINITI, Daniel; US
RAJESH, Mathur, P.; US
KAPILA, Shubhender; US
Agent:
ROEDEL, John, K., Jr. ; Senniger, Powers, Leavitt and Roedel 16th floor One Metropolitan Square St. Louis, MO 63102, US
Priority Data:
60/162,72529.10.1999US
Title (EN) OLIGOMERS AND OLIGOMERIC SEGMENTS OF ALPHA-HYDROXY CARBOXYLIC ACIDS AND ALPHA-AMINO ACIDS
(FR) OLIGOMERES ET SEGMENTS OLIGOMERES D'ACIDES $g(a)-HYDROXYCARBOXYLIQUES ET D'ACIDES $g(a)-AMINES
Abstract:
(EN) An enzymatic synthesis and composition of $g(a)-hydroxy carboxylic acid and $g(a)-amino acid or peptide co-oligomers is disclosed wherein a residue of the $g(a)-hydroxy carboxylic acid is linked to a residue of the $g(a)-amino acid or peptide by an amide linkage. Proteolytic enzyme papain catalyzes co-oligomerization of the $g(a)-hydroxy carboxylic acid and $g(a)-amino acid. The degree and distribution of oligomerization varies upon the type and concentrations of different reaction mixtures utilized and upon the length of allowed reaction time. The resultant oligomers may be provided to ruminants as bioavailable amino acid supplements that are resistant to degradation in the rumen.
(FR) Synthèse enzymatique et composition d'acide $g(a)-hydroxycarboxylique et d'acide $g(a)-aminé ou de co-oligomères de peptides consistant à effectuer la liaison d'un résidu de l'acide $g(a)-hydroxycarboxylique et d'un résidu de l'acide $g(a)-aminé ou du peptide au moyen d'une liaison amide. La papaïne enzymatique protéolytique catalyse la co-oligomérisation de l'acide $g(a)-hydroxycarboxylique et de l'acide $g(a)-aminé. Le degré et la répartition de l'oligomérisation varient en fonction du type et des concentrations de différents mélanges réactionnels utilisés et de la longueur de la durée réactionnelle permise. On peut donner les oligomères obtenus à des ruminants en tant que compléments aminoacides biodisponibles résistant à la dégradation dans la panse.
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Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)