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1. (WO2001032889) MURINE SERINE/THREONINE KINASE, YAK3

Pub. No.:    WO/2001/032889    International Application No.:    PCT/US2000/030505
Publication Date: Fri May 11 01:59:59 CEST 2001 International Filing Date: Tue Nov 07 00:59:59 CET 2000
IPC: C12N 9/12
Applicants: SMITHKLINE BEECHAM CORPORATION
SMITHKLINE BEECHAM PLC.
Inventors: CREASY, Caretha, Lee
HUGHES, Stephen, Anthony
WOJCHOWSKI, Don, Michael
Title: MURINE SERINE/THREONINE KINASE, YAK3
Abstract:
Mus Musculus YAK3 polypeptides and polynucleotides and method for producing such polypetides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds that either agonize or antagonize Mus Musculus YAK3. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: neutropenia; cytopenia; anemias, including anemias due to renal insufficiency or to chronic disease, such as autoimmunity or cancer, and drug-induced anemias; polycythemia; myelosuppression; infertility; bone loss including osteoporosis; inflammatory diseases such as Adult Respiratory Disease Syndrome (ARDS), Rheumatoid arthritis, Osteoarthritis, Inflammatory Bowel Disease (IBD), psoriasis, dermatitis, asthma, allergies; infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; HIV-associated cachexia and other immunodeficiency disorders; septic shock; pain; injury; cancers including testicular cancer; anorexia; bulimia; Parkinson's disease; cardiovascular disease including restenosis, atherosclerosis, acute heart failure, myocardial infarction; hypotension; hypertension; urinary retention; angina pectoris; ulcers; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles de la Tourett's syndrome.