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1. (WO2001032885) HUMAN LIPASE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/032885 International Application No.: PCT/US2000/030514
Publication Date: 10.05.2001 International Filing Date: 03.11.2000
Chapter 2 Demand Filed: 05.06.2001
IPC:
A61K 31/7088 (2006.01) ,A61K 38/00 (2006.01) ,A61K 48/00 (2006.01) ,C12N 9/20 (2006.01) ,C12Q 1/44 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
16
acting on ester bonds (3.1)
18
Carboxylic ester hydrolases
20
Triglyceride splitting, e.g. by means of lipase
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
34
involving hydrolase
44
involving esterase
Applicants: KAPELLER-LIBERMANN, Rosana[BR/US]; US (UsOnly)
RUDOLPH-OWEN, Laura, A.[US/US]; US (UsOnly)
MILLENNIUM PHARMACEUTICALS, INC.[US/US]; 75 Sidney Street Cambridge, MA 02139, US (AllExceptUS)
Inventors: KAPELLER-LIBERMANN, Rosana; US
RUDOLPH-OWEN, Laura, A.; US
Agent: SPRUILL, W., Murray ; Alston & Bird LLP Bank of America Plaza 101 South Tyron Street , suite 4000 Charlotte, North Carolina 28280-4000, US
Priority Data:
09/435,31105.11.1999US
09/704,91802.11.2000US
Title (EN) HUMAN LIPASE
(FR) 18892, NOUVELLE LIPASE HUMAINE
Abstract:
(EN) The present invention relates to a newly identified human lipase belonging to the family of mammalian lipases. The invention also relates to polynucleotides encoding the lipase. The invention further relates to methods using the lipase polypeptides and polynucleotides as a target for diagnosis and treatment in lipase-mediated or -related disorders. The invention further relates to drug-screening methods using the lipase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the lipase polypeptides and polynucleotides. The invention further relates to procedures for producing the lipase polypeptides and polynucleotides.
(FR) La présente invention se rapporte à une lipase humaine récemment identifiée qui appartient à la famille des lipases mammaliennes. L'invention se rapporte également à des polynucléotides codant pour cette lipase. Elle se rapporte aussi à des méthodes utilisant les polypeptides et polynucléotides associés à cette lipase en tant que cible pour le diagnostic et le traitement des troubles liés à une lipase ou à médiation assurée par une lipase. L'invention se rapporte à des méthodes de sélection de médicaments utilisant les polypeptides et polynucléotides associés à cette lipase pour identifier des agonistes et antagonistes à des fins diagnostiques et thérapeutiques. L'invention se rapporte en outre à des agonistes et antagonistes basés sur les polypeptides et polynucléotides associés à cette lipase, ainsi qu'à des procédures de production des polypeptides et polynucléotides associés à cette lipase.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)