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1. (WO2001032877) CpG RECEPTOR (CpG-R) AND METHODS RELATING THERETO
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/032877 International Application No.: PCT/US2000/041735
Publication Date: 10.05.2001 International Filing Date: 01.11.2000
Chapter 2 Demand Filed: 31.05.2001
IPC:
C07K 14/705 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
Applicants: MACKICHAN, Mary, Lee[US/US]; US (UsOnly)
CHIRON CORPORATION[US/US]; 4560 Horton Street Emeryville, CA 94608, US (AllExceptUS)
Inventors: MACKICHAN, Mary, Lee; US
Agent: HARBIN, Alisa, A.; Chiron Corporation Intellectual Property - R440 P.O. Box 8097 Emeryville, CA 94662-8097, US
Priority Data:
60/163,15702.11.1999US
60/167,38924.11.1999US
Title (EN) CpG RECEPTOR (CpG-R) AND METHODS RELATING THERETO
(FR) RECEPTEUR DE CpG (CpG-R) ET PROCEDES CORRESPONDANTS
Abstract:
(EN) The present invention is directed to nucleic acid molecules and polypeptides encoding a CpG receptor (CpG-R). The CpG-R contains a THD, interacts with the MyD88 adapter protein, and may bind to CpG oligonucleotides. The present invention is also directed to antibodies against CpG-R and to methods of modulating an immune response and to methods of identifying compounds which bind to and/or modulate CpG-R.
(FR) L'invention concerne des molécules d'acides nucléiques et des polypeptides codant un récepteur de CpG (CpG-R). Le CpG-R renferme un domaine d'homologie Toll (THD), interagit avec la protéine d'adaptation MyD88, et peut se lier avec des oligonucléotides CpG. L'invention concerne également des anticorps vis-à-vis du CpG-R, des procédés de modulation de réponse immunitaire et des procédés relatifs à l'identification de composés qui se lient avec le CpG-R et/ou modulent le CpG-R.
front page image
Designated States: CA, JP, US
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
Publication Language: English (EN)
Filing Language: English (EN)