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1. (WO2001032702) MOLECULAR STRUCTURE OF RHD NEGATIVE LOCUS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/032702 International Application No.: PCT/EP2000/010745
Publication Date: 10.05.2001 International Filing Date: 31.10.2000
Chapter 2 Demand Filed: 05.06.2001
IPC:
C07K 14/705 (2006.01) ,C12Q 1/68 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants: FLEGEL, Willy, A.[DE/DE]; DE (UsOnly)
WAGNER, Franz, F.[DE/DE]; DE (UsOnly)
DRK BLUTSPENDEDIENST BADEN-WUERTTEMBERG GGMBH[DE/DE]; Helmholtzstrasse 10 89081 Ulm, DE (AllExceptUS)
Inventors: FLEGEL, Willy, A.; DE
WAGNER, Franz, F.; DE
Agent: VOSSIUS & PARTNER; Siebertstrasse 4 81675 München, DE
Priority Data:
00111696.131.05.2000EP
99121686.202.11.1999EP
Title (EN) MOLECULAR STRUCTURE OF RHD NEGATIVE LOCUS
(FR) STRUCTURE MOLECULAIRE DE RDH NEGATIF
Abstract:
(EN) The present invention relates to a nucleic acid molecular structure representing the Rhesus genes locus comprising the RHD, SMP1 and RHCE genes and/or the Rhesus box(es), preferably the hybrid Rhesus box, the upstream Rhesus box and/or the downstream Rhesus box. Furthermore, the invention relates to a process for the specific detection of the common RHD negative haplotypes. The invention further relates to the detection of RHD positive haplotypes in D-negative individuals. Various mutations in the RHD gene have been identified that allow for the development of diagnostic tools. The invention also relates to oligonucleotides, that specifically hybridize to the hybrid box, preferably the breakpoint or breakpoint region or to the upstream and downstream Rhesus boxes. Additionally, the invention relates to kits comprising or employing the above recited compounds of the invention.
(FR) La présente invention concerne une structure moléculaire d'acide nucléique représentant le locus de gènes de Rhésus, comprenant les gènes RHD, SMP1 et RHCE et/ou la (les) séquence(s) Rhésus, de préférence la séquence Rhésus hybride, la séquence Rhésus amont et/ou aval. De plus, l'invention concerne un processus de détection spécifique d'haplotypes RHD négatifs. L'invention concerne également la détection d'haplotypes RHD positifs chez des individus D-négatifs. Diverses mutations du gène RHD ont été identifiées permettant le développement d'outils diagnostics. L'invention concerne également des oligonucléotides s'hybridant spécifiquement à la séquence hybride, de préférence le point de cassure ou la région de cassure ou aux séquences Rhésus amont et aval. De plus, l'invention concerne des matériels comprenant ou utilisant les composés précités de l'invention.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)