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1. (WO2001032701) A NEW POLYPEPTIDE - SUBUNIT 15 OF HUMAN F1F0 ATP SYNTHASE AND A POLYNUCLEOTIDE ENCODING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/032701 International Application No.: PCT/CN2000/000403
Publication Date: 10.05.2001 International Filing Date: 30.10.2000
Chapter 2 Demand Filed: 21.05.2001
IPC:
A61K 38/00 (2006.01) ,C12N 9/14 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
Applicants: MAO, Yumin[CN/CN]; CN (UsOnly)
XIE, Yi[CN/CN]; CN (UsOnly)
SHANGHAI BIO DOOR GENE TECHNOLOGY LTD.[CN/CN]; 12th Floor 3rd Building No. 1111, Zhongshan Bei Er Road Shanghai 200092, CN (AllExceptUS)
Inventors: MAO, Yumin; CN
XIE, Yi; CN
Agent: SHANGHAI ZHI XIN PATENT AGENT LTD.; 10/F, Italy Building 446 Zhao Jia Bang Road Shanghai 200031, CN
Priority Data:
99119920.029.10.1999CN
Title (EN) A NEW POLYPEPTIDE - SUBUNIT 15 OF HUMAN F1F0 ATP SYNTHASE AND A POLYNUCLEOTIDE ENCODING THE SAME
(FR) NOUVEAU POLYPEPTIDE, SOUS-UNITE 15 DE LA SYNTHASE HUMAINE F1F0 ATP, ET POLYNUCLEOTIDE CODANT POUR CE POLYPEPTIDE
Abstract:
(EN) The present invention discloses a new polypeptide-subunit 15 of human F1F0 ATP synthase and a polynucleotide encoding the same, as well as a method of producing the polypeptide by DNA recombinant technology. The present invention also discloses methods of using the polypeptide in treatment of various disease, especially in treatment of energy metabolism and material metabolism disorder, such as DOWN syndrome, BATTEN condition, Alzheimer's disease, some tumors, some genetic disease, blood disease, and immunological disease. The present invention also discloses an antagonist against the polypeptide and the therapeutic use of the same. The present invention also discloses the use of such polynucleotide encoding the subunit 15 of human F1F0 ATP synthase.
(FR) L'invention concerne un nouveau polypeptide, une sous-unité 15 de la synthase humaine F1F0 ATP, et un polynucléotide codant pour ce polypeptide ainsi qu'un procédé d'obtention de ce polypeptide par des techniques recombinantes d'ADN. L'invention concerne en outre les applications de ce polypeptide dans le traitement de maladies, notamment des tumeurs malignes, de l'hémopathie, de l'infection par VIH, de maladies immunitaires et de diverses inflammations. L'invention concerne aussi l'antagoniste agissant contre le polypeptide et son action thérapeutique ainsi que les applications de ce polynucléotide codant pour la sous-unité 15 de la synthase humaine F1F0 ATP.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)