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1. (WO2001032673) SEQUENCES ENCODING HUMAN NEOPLASTIC MARKER

Pub. No.:    WO/2001/032673    International Application No.:    PCT/US2000/030190
Publication Date: Fri May 11 01:59:59 CEST 2001 International Filing Date: Thu Nov 02 00:59:59 CET 2000
IPC: C07K 16/40
C12N 9/02
C12Q 1/68
Applicants: PURDUE RESEARCH FOUNDATION
MORRE, D., James
MORRE, Dorothy, M.
CHUEH, Pin-Ju
Inventors: MORRE, D., James
MORRE, Dorothy, M.
CHUEH, Pin-Ju
Title: SEQUENCES ENCODING HUMAN NEOPLASTIC MARKER
Abstract:
The present disclosure provides the nucleotide sequence encoding a cell surface NADH oxidase/protein disulfide-thiol interchange protein (tNOX) characteristic of neoplastic and virus-infected cells. Also provided are recombinant DNA molecules comprising a sequence portion encoding full length or truncated tNOX, recombinant host cell which express ful length or truncated tNOX, methods for recombinant production of tNOX or truncated tNOX, and diagnostic methods which employ either nucleotide sequences of the neoplastic cell-specific tNOX or antibodies specific for the rNOX protein.