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1. (WO2001032655) QUINOLINE AND NAPHTHYRIDINE CARBOXYLIC ACID ANTIBACTERIALS

Pub. No.:    WO/2001/032655    International Application No.:    PCT/US2000/030551
Publication Date: Fri May 11 01:59:59 CEST 2001 International Filing Date: Tue Nov 07 00:59:59 CET 2000
IPC: C07D 405/04
C07D 409/04
C07D 409/14
C07D 413/14
C07D 417/14
C07D 471/04
C07D 495/04
C07D 513/04
C07D 519/00
Applicants: ABBOTT LABORATORIES
Inventors: ELMORE, Steven, W.
COOPER, Curt, S.
SCHULTZ, Colleen, C.
HUTCHINSON, Douglas, K.
DONNER, Pamela, L.
GREEN, Brian, E.
ANDERSON, David, D.
XIE, Qinghua
DINGES, Jurgen
LYNCH, Linda, M.
Title: QUINOLINE AND NAPHTHYRIDINE CARBOXYLIC ACID ANTIBACTERIALS
Abstract:
Compounds having formula (I), or pharmaceutically acceptable salts or prodrugs thereof, wherein A1 is nitrogen or (II), wherein W is selected from the group consisting of (1) hydrogen and (2) optionally substituted alkyl; A2 is selected from the group consisting of (1) -S-, (2) -O-, and (3) -N(R7)-, wherein R7 is hydrogen or C¿1?-C6 alkyl; and R?5 and R6¿ together are a carbocyclic or a heterocyclic ring, are useful as antibacterial agents.