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1. (WO2001032654) NOVEL HETEROCYCLIC COMPOUNDS AND THEIR USE AS MEDICINES

Pub. No.:    WO/2001/032654    International Application No.:    PCT/FR2000/003067
Publication Date: Fri May 11 01:59:59 CEST 2001 International Filing Date: Sat Nov 04 00:59:59 CET 2000
IPC: C07D 263/24
C07D 307/24
C07D 405/12
C07D 407/12
C07D 413/12
Applicants: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.)
AUVIN, Serge
CHABRIER de LASSAUNIERE, Pierre-Etienne
Inventors: AUVIN, Serge
CHABRIER de LASSAUNIERE, Pierre-Etienne
Title: NOVEL HETEROCYCLIC COMPOUNDS AND THEIR USE AS MEDICINES
Abstract:
The invention concerns novel heterocyclic derivatives having a calpain inhibiting activity and/or an activity trapping reactive oxygen species, of formula (I) wherein A, X, Y, R1, R2 and Het represent variable groups. The invention also concerns methods for preparing said compounds, pharmaceutical preparations containing them and their therapeutic use, in particular as calpain inhibitors and/or as trapping agents for reactive oxygen species, whether selectively or not.