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1. (WO2001032604) ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE
Note: Text based on automatic Optical Character Recognition processes. Please use the PDF version for legal matters

CLAIMS

1. Use of a compound of the formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in the activation of soluble guanylate cyclase


wherein:

- R1 and R2 are the same or different and each represent a C1-C6 alkyl group, or R1 and R2 together form a C3-C6 alkylene group;

Z is a C1-C4 alkylene group;

P is a direct bond or a moiety -X-, -Y-, -W-, -XY-, -YW- or -XYW-, wherein:

- W is -O-, -S-, or -NR3, wherein R3 is hydrogen or C1-C6 alkyl;

Y is a moiety -U-V- wherein V is a direct bond or a C1-C6 alkylene group and U is -CS-, -CO-, -S(O)2- or -C(=NR)- wherein R is hydrogen, hydroxy or C1-C6 alkyl;

X is -O- or -NR6- wherein R6 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, aryl or heteroaryl; and

R4 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, aryl, heteroaryl, carbocyclyl, heterocyclyl, a group -R-A wherein R is -(C1-C6 alkyl)-, -(C2-C6 alkenyl)- or -(C2-C6 alkynyl)- and A is aryl, heteroaryl, carbocycyl or heterocyclyl, or R4 is a group -COR//, -COzR//, -S(O)2R// or -CONR/R// wherein R/ is hydrogen, C1-C6 alkyl, C2-C6 alkenyl or

C2-C6 alkynyl and R// is is aryl, heteroaryl, carbocyclyl or heterocyclyl.

2. Use according to claim 1, wherein R1 and/or R2 are methyl.

3. Use according to claim 1 or 2, wherein Z is propylene.

4. Use according to any one of the preceding claims, wherein P is -XYW- or -YW-.

5. Use according to any one of the preceding claims, wherein W is -O- or -NR3- wherein R3 is as defined in claim 1.

6. Use according to any one of the preceding claims, wherein Y is -CO-.

7. Use according to any one of the preceding claims wherein X is -NH-.

8. Use according to any one of the preceding claims wherein R4 is C1-C6 alkyl, aryl, heteroaryl, carbocyclyl, heterocyclyl, -(C1-C6 alkyl)-aryl, -(C1-C6 alkyl)- heteroaryl or -COR// , -CO2R// or -CONR/R// wherein R/ is hydrogen or C1-C6 alkyl and R// is an aryl, heteroaryl, carbocyclyl or heterocyclyl group.

9. Use according to any one of the preceding claims, wherein P is -XYW-, X is - NH- and R4 is phenyl, thienyl or pyrazolyl.

10. Use according to any one of claims 1 to 8, wherein P is -YW- and R4 is a chromonyl, pyrazolyl, thienyl, phenyl or indolyl group.

11. Use according to claim 1, wherein the compound of formula (I) is

1-(3-Dimethylamino-propyl)-3-(2-phenoxy-phenyl)-urea

1-[2-(4-Chloro-phenoxy)-pyridin-3-yl]-3-(3-dimethylaminopropyl)-urea

1-(3-Dimethylamino-propyl)-3-pyren-1-ylmethyl-urea

1-(3-Dimethylamino-propyl)-3-[(1R,2R)-5-phenyl-2-(1-phenyl-methanoyl)- cyclohexyl]-urea

1-(3-Dimethylamino-propyl)-3-[2-(4-phenoxy-phenyl)-ethyl]-urea

1-(3-Dimethylamino-propyl)-3-[3-methyl-5-(4-methyl-[1,2,3]thiadiazol-5-yl)-1-(4-trifluoromethoxy-phenyl)-1H-pyrazol-4-yl]-urea

2'-[3-(3-Dimethylamino-propyl)-ureido]-biphenyl-2-carboxylic acid (4-fluoro-phenyl)-amide

N-(3-Chloro-4-methyl-phenyl)-4-[3-(3-dimethylamino-propyl)-ureido]-3-phenyl-butyramide

1-[4-(4-Chloro-phenylsulfanyl)-thiophen-3-yl]-3-(3-dimethylamino-propyl)-urea

1-[2-(3,4-Dimethoxy-phenyl)-6-methyl-quinolin-4-yl]-3-(4-dimethylamino-propyl)-urea

1-(6-Bromo-2-thiophen-3-yl-quinolin-4-yl)-3-(3-dimethylamino-propyl)-urea

1-[3-(4-Chloro-phenyl)-4-cyano-5-isobutyIsulfanyl-thiophen-2-yl]-3-(3-dimethylamino-propyl)-urea

1-[6-(2,4-Dichloro-phenyl)-cyclohex-3-enyl]-3-(3-dimethylamino-propyl)-urea

1-(2-Benzylsulfanyl-phenyl)-3-(3-dimethylamino-propyl)-urea

2-{2-[3-(3-Dimethylamino-propyl)-ureido]-phenylsulfanyl}-N-phenyl-benzenesulfonamide

1-(3-Dimethylamino-propyl)-3-(2'-fluoro-biphenyl-4-yl)-urea

N-(3,5-Dichloro-phenyl)-2-{3-[3-(3-dimethylamino-ρropyl)-ureido]-pyridin- 2-ylsulfanyl}-acetamide

1 -(3 -Dimethylamino-propyl)-3-{2-[1-(1-trifluoromethyl-1,3,4,9-tetrahydro-b-carbolin-2-yl)-methanoyl]-phenyl}-urea

8-{2-[3-(3-Dimethylamino-propyl)-ureido]-phenylsulfanyl}-naphthalene-1-carboxylic acid methylamide

1-[1-(3,4-Dichloro-benzyl)-6-oxo-1,6-dihydro-pyridin-3-yl]-3-(3-dimethylamino-propyl)-urea

1-(3-Dimethylamino-propyl)-3-(3-oxo-1,2,3-triphenyl-propyl)-urea

1-[5-(4-Chloro-phenyl)-1-(3,4-dichloro-phenyl)-1H-pyrazol-3-yl]-3-(3-dimethylamino-propyl)-urea

1-{4-[4-(4-Chloro-phenyl)-thiazol-2-yl]-phenyl}-3-(3-dimethylamino-propyl)-urea

1-(3-Dimethylamino-propyl)-3-[5-(4-fluoro-phenyl)-thiophen-2-yl]-urea

1-[3-(4-tert-Butyl-benzyloxy)-thiophen-2-yl]-3-(3-dimethylamino-propyl)-urea

1-(3-Dimethylamino-propyl)-3-[4-(4-phenyl-thiazol-2-yl)-phenyl]-urea 1-[3-(3,4-Dichloro-benzylsulfanyl)-thiophen-2-yl]-3-(3-dimethylamino-propyl)-urea

1-[2-(5-Chloro-1-methyl-3-phenyl-1H-pyrazol-4-ylmethylsulfanyl)-phenyl]-3-(3-dimethylamino-propyl)-urea

1-[2-(4-Chloro-benzylsulfanyl)-3-methyl-4-oxo-3,4-dihydro-quinazolin-7-yl]-3-(3-dimethylamino-propyl)-urea

1-(3-Dimethylamino-propyl)-3-{4-[4-(4-methoxy-phenyl)-pyrimidin-2-ylsulfanylmethyl]-phenyl}-urea

1-(4-Bromophenyl)-3-(3-(1-pyrrolidinyl) propyl) urea

1-(4-Bromophenyl)-3-(3-dimethylamino propyl) urea

3-(4-Bromophenyl)-1-methyl-1-(3-dimethylamino propyl) urea

1-(3-Phenyl-5-methoxy phenyl)-3-(3-dimethylamino propyl) urea

3-(4-Chlorophenyl)-1-methyl-1-(3-dimethylamino propyl) urea

1-(3-Nitrophenyl)-1-benzyl-3-(3-dimethylamino propyl) urea

1-Benzyl-1-(4-methyl-3-pyridinyl)-3-(3-dimethylamino propyl) urea

1-Methyl-1-(3,5-bistrifluoromethylphenyl)-3-(3-dimethylaminopropyl)urea 1-(2-Phenacyl-4-chorophenyl)-1-methyl-3-(3-dimethylamino propyl) urea 1-(2-Chloro-4-trifluoromethylphenyl)-3-(3-dimethylaminopropyl) urea 1-(3-Fluoro-5-trifluoromethylphenyl)-3-(3-dimethylaminopropyl) urea 1-(3-N-tert-butoxycarbonyl-benzylamino)-3-(3-dimethylaminopropyl) urea N-(3-Dimethylamino-propyl)-2-[1-(4-fluorobenzoyl]-benzamide

2-[1-(4-Chlorobenzoyl]-N-(3-dimethylamino-propyl)-benzamide

5-(4-Chloro-phenyl)-1-phenyl-1H-pyrazole-3-carboxylic acid (3-dimethylamino-propyl)-amide

5-Chloro-3-phenyl-1H-indole-2-carboxylic acid (3-dimethylamino-propyl)-amide

N-(3-Dimethylamino-propyl)-2-(2-phenylsulfamoyl-phenylsulfanyl)-benzamide

2-Benzylsulfanyl-N-(3-dimethylamino-propyl)-benzamide

6,8-Di-tert-butyl-4-oxo-4H-chromene-2-carboxylic acid (3-dimethylamino -propyl)-amide

3-(4-Chloro-phenyl)-4-cyano-5-isobutylsulfanyl-thiophene-2-carboxylic acid (3-dimethylamino-propyl)-amide

4-(4-Chloro-phenoxy)-N-(3-dimethylamino-propyl)-3-nitro-benzamide N-(3-Dimethylamino-propyl)-4-(4-phenyl-thiazol-2-yl)-benzamide

1-(3-Dimethylamino-propyl)-3-(2-phenoxyphenyl)-urea

1-[4-(4-Chloro-phenylsulfanyl)-thiophen-3-yl]-3-(3-dimethylamino-propyl)

-urea

1-(3-Dimethylamino-propyl)-3-(2'-fluoro-biphenyl-4-yl)-urea

N-(3-Dimethylamino-propyl)-2-[1-(4-fluorobenzoyl]-benzamide

N-(3-Dimethylamino-propyl)-3-phenoxy-benzamide

N-(3-Dimethylamino-propyl)-2-phenoxy-benzamide

2-(4-Chloro-phenoxy)-N-(3-dimethylamino-propyl)-nicotinamide

4'-n-Propyl-biphenyl-4-carboxylic acid (3-dimethylamino-propyl)-amide 2-[1-(4-Bromo-phenyl)-methanoyl]-cyclohexanecarboxylic acid (3-dimethylamino-propyl)-amide

5-(3-Trifluoromethyl-phenyl)-furan-2-carboxylic acid (3-dimethylamino-propyl)-amide

2-[1-(4-Chlorobenzoyl]-N-(3-dimethylamino-propyl)-benzamide

2-Phenyl-quinoline-4-carboxylic acid (3-dimethylamino-propyl)-amide

2-[1-(4-Chloro-3-nitrobenzoyl)]-N-(3-dimethylamino-propyl)-benzamide

N-(3 -Dimethylamino-propyl)-2-pyren-1-yl-acetamide

N-(3-Dimethylamino-propyl)-2-[1-(3-methyl-benzo[b]thiophen-2-yl)-methanoylj-benzamide

4-Chloro-N-(3-dimethylamino-propyl)-2-phenoxy-benzamide

N-(3-Dimethylamino-propyl)-3-(4-phenoxy-phenyl)-propionamide

N-(3 -Dimethylamino-propyl)-2-[1-(1-trifluoromethyl-1,3,4,9-tetrahydro-b-carbolin-2-yl)-methanoyl]-benzamide

1-(4-Chloro-phenyl)-2,5-dimethyl-1-pyrrole-3-carboxylic acid (3-dimethylamino-propyl)-amide

2-{ 1-[(3-Dimethylamino-propylcarbamoyl)-methyl]-cyclopentyl}-N-(4-trifluoromethoxy-phenyl)-acetamide

8-[2-(3-Dimethylamino-propylcarbamoyl)-phenylsulfanyl]-naphthalene-1-carboxylic acid methylamide

3-Methyl-5-(4-methyl-[1,2,3]thiadiazol-5-yl)-1-(4-trifluoromethoxy-phenyl)-1H-pyrazole-4-carboxylic acid (3 -dimethy lamino-propyl)-amide

6,8-Di-tert-butyl-4-oxo-4H-chromene-2-carboxylic acid (3-dimethylamino-propyl)-amide

2-(Furan-2-yl)-quinoline-4-carboxylic acid (3-dimethylamino-propyl)-amide Biphenyl-2,2'-dicarboxylic acid 2'-[(3-dimethylamino-propyl)-amide]-2-[(4-fluoro-phenyl)-amide]

3-Phenyl-pentanedioic acid (3-chloro-4-methyl-phenyl)-amide (3-dimethylamino-propyl)-amide

2-(3,4-Dimethoxy-phenyl)-6-methyl-quinoline-4-carboxylic acid (3-dimethylamino-propyl)-amide

6-Bromo-(2-thiophen-3-yl)-quinoline-4-carboxylic acid (3-dimethylamino-propyl)-amide

3-(4-Chloro-phenyl)-4-cyano-5-isobutylsulfanyl-thiophene-2-carboxylic acid

(3 -dimethylamino-propyl)-amide

4-(4-Chloro-phenoxy)-N-(3-dimethylamino-propyl)-3-nitro-benzamide

6-(2,4-Dichloro-phenyl)-cyclohex-3-ene carboxylic acid (3-dimethylamino-propyl)-amide

N-(3-Dimethylamino-propyl)-2-(2-phenylsulfamoyl-phenylsulfanyl)-benzamide

2'-Fluoro-[1,1'-biphenyl]-4-carboxylic acid (3-dimethylamino-propyl)-amide

2-Benzylsulfanyl-N-(3-dimethylamino-propyl)-benzamide

Pyrazine-2,3-dicarboxylic acid 2-[(3-dimethylamino-propyl)-amide] 3- [(5,6,7,8-tetrahydro-naphthalen-1-yl)-amide]

2-[(3,5-Dichloro-phenylcarbamoyl)-methylsulfanyl]-N-(3-dimethylamino-propyl)-nicotinamide

2-(3-Trifluoromethyl-phenyl)-thiazole-4-carboxylic acid (3-dimethylamino-propyl)-amide

2-(4-Chloro-phenyl)-thiazole-4-carboxylic acid (3-dimethylamino-propyl)-amide

5-Chloro-1-(2,4-dichloro-benzyl)-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid (3-dimethylamino-propyl)-amide

1-(2,4-Dichloro-benzyl)-6-oxo-l ,6-dihydro-pyridine-3-carboxylic acid (3-dimethylamino-propyl)-amide

5-Chloro-1-(3,4-dichloro-benzyl)-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid (3-dimethylamino-propyl)-amide

1-(3,4-Dichloro-benzyl)-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid (3-dimethylamino-propyl)-amide

5-Chloro-1-(2,6-dichloro-benzyl)-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid (3-dimethylamino-propyl)-amide

1,1-Dimethyl-indan-4-carboxylic acid (3-dimethylamino-propyl)-amide

N-(3-Dimethylamino-propyl)-2-[1-(4-ethyl-phenyl)-methanoyl]-benzamide

N-(3-Dimethylamino-propyl)-3-(2,4,5-trimethyl-phenyl)-butyramide

2-[3-(3,4-Dichloro-phenyl)-ureido]-N-(3-dimethylamino-propyl)-benzamide N-(3-Dimethylamino-propyl)-4-oxo-2,3,4-triphenyl-butyramide

5-(4-Chloro-phenylsulfanyl)-[1,2,3]thiadiazole-4-carboxylic acid (3-dimethylamino-propyl)-amide

2-(3-Chloro-5-trifluoromethyl-pyridin-2-ylsulfanyl)-3-methyl-3H-imidazole-4-carboxylic acid (3-dimethylamino-propyl)-amide

2-(2-Chloro-4-trifluoromethyl-phenyl)-[1,3]-thiazole-4-carboxylic acid (3-dimethylamino-propyl)-amide

2-(2,3-Dihydro-1-benzofuran-5-yl)-1,3-thiazole-4-carboxylic acid (3-dimethylamino-propyl)-amide

2-(2,3-Dichloro-phenyl)-1,3-thiazole-4-carboxylic acid (3-dimethylamino-propyl)-amide

4-[4-(4-Chloro-phenyl)-thiazol-2-yl]-N-(3-dimethylamino-propyl)-benzamide

5-(4-Fluoro-phenyl)-thiophene-2-carboxylic acid (3-dimethylamino-propyl)-amide

4-Methyl-2-(3-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid (3-dimethylamino-propyl)-amide

3-(4-tert-Butyl-benzyloxy)-thiophene-2-carboxylic acid (3-dimethylamino-propyl)-amide

4-Oxo-3-(3-trifluoromethyl-phenyl)-3,4-dihydro-phthalazine-1-carboxylic acid (3-dimethylamino-propyl)-amide

2-(4-Chloro-phenyl)-N-(3-dimethylamino-propyl)-4-oxo-4-phenyl-butyramide

5-(4-Chloro-phenyl)-1-phenyl-1H-pyrazole-3-carboxylic acid (3-dimethylamino-propyl)-amide

N-(3-Dimethylamino-propyl)-4-(4-phenyl-thiazol-2-yl)-benzamide

1-(2,4,5-Trichloro-phenylsulfonyl)-pyrrolidine-2-carboxylic acid (3-dimethylamino-propyl)-amide

3-(3,4-Dichloro-benzylsulfanyl)-thiophene-2-carboxylic acid (3-dimethylamino-propyl)-amide

5-Chloro-3-phenyl-1H-indole-2-carboxylic acid (3-dimethylamino-propyl)-amide

N-(3-Dimethylamino-propyl)-2-[1-(4-fluoro-benzyl)-1H-indol-3-yl]-acetamide

2-Phenyl-imidazo[1,2-a]pyridine-3-carboxylic acid (3-dimethylamino-propyl)-amide

N-(3-Dimethylamino-propyl)-2-(7-ethyl-1H-indol-3-yl)-4-oxo-4-phenyl-butyr amide

Phenyl-trifluoromethyl-thieno[3,2-b]pyridine-2-carboxylic acid (3-dimethylamino-propyl)-amide

3-(4-Nitro-3-trifluoromethyl-phenoxy)-thiophene-2-carboxylic acid (3-dimethylamino-propyl)-amide

2-(5-Chloro-1-methyl-3-phenyl-1H-pyrazol-4-ylmethylsulfanyl)-N-(3-dimethylamino-propyl)-benzamide

2-(4-Chloro-benzylsulfanyl)-3-methyl-4-oxo-3,4-dihydro-quinazoline-7

-carboxylic acid (3-dimethylamino-propyl)-amide

N-(3-Dimethylamino-propyl)-4-[4-(4-methoxy-phenyl)-pyrimidin-2

-ylsulfanylmethyl]-benzamide

1-(4-chlorobenzyl)-3-(2-N,N-dimethylethylamido)-6-pyridone

1-(2,6-dichlorobenzyl)-3-(3-N,N-dimethylpropylamido)-6-pyridone

1-(3-trifluoromethylbenzyl)-3-(2-N,N-dimethylethylamido)-2-pyridone 1-(2,6-dichlorobenzyl)-3-(2-N,N-dimethylethylamido)-2-pyridone

1-(3,4-dichlorobenzyl)-3-(N-[2,N,N-dimethylaminoethylamido])-2-pyridone 1-(2,6-dichlorobenzyl)-3-(N-[2-N,N-dimethylaminoethylamido])-6-pyridone 5-chloro-1-(3,4-dichlorobenzyl)-3-(2-N,N-dimethylaminoethylamido)-6

-pyridone

5-chloro-3-(2-N,N-dimethylaminoethylamido)-1-(3-trifluoromethylbenzyl)-6-pyridone

5-chloro-1-(3,4-dichlorobenzyl)-3-N-(2-[N',N'-dimethylaminoethylamido])-2-pyridone

5-chloro-1-(4-chlorobenzyl)-3-N-(2-(N',N'-dimethylamino)ethyl)amido-2-pyridone

5-chloro-1-(3-trifluoromethylbenzyl)-3-N-(2-(N',N'-dimethylamino)ethyl) amido-2-pyridone

1-benzyl-5-chloro-3-N-(2-[N',N'-dimethylamino]ethyl)carboxamido-6-pyridone

5-chloro-1-(4-chlorobenzyl)-3-N-(2-[N',N'-dimethylamino]ethyl)carboxamido -6-pyridone

4-(2,4-dichlorobenzoyl)pyrrole-2-N-dimethylaminopropylcarboxamide

4-[(N-[3-(N',N'-dimethylaminopropyl)]carboxamido]-2-phenylthiazole

4-(N-(3-N',N'-dimethylaminopropyl)carboxamido)-2-(4-pyridinyl)thiazole

2-[4-(N-[3-N',N'-dimethylaminopropyl]carboxamido)phenyl-4-(3-trifluoromethylphenyl)]thiazole

4-(4-chlorophenyl)-2-(4-[3-N',N'-dimethylaminopropyl]carboxamido)phenyl) thiazole

1-(3,5-bis(trifluoromethyl)benzyl)-3-[N-(2-dimethylaminoethyl)

carboxamido]-2[1H]-pyridone

N-(3-dimethylaminopropyl)-4-(3-chloro-5-trifluoromethyl-2-pyridyloxy) phenylsulfonamide

N 1-[3-(dimethylamino)propyl]-3-[3-chloro-5-(trifluoromethyl)-2-pyridyl] propanamide

3-(N-(2-dimethylaminoethyl)carboxamido]-1-(4-trifluoromethylbenzyl))-2 [1H]-pyridone

1-ethyl-3-(3-dimethylaminopropyl)urea

1 -(3 -(dimethylamino)-propyl)-3 -phenylurea

N 1-[2-(2,4-dichlorophenoxy)phenyl]-N2-[3-(dimethylamino)propyl] ethanediamide

N4-[3-(dimethylamino)propyl]-3-(2,6-dichlorophenyl)-5-methylisoxazole-4-c arboxamide

N-[[3-(2,6-dichlorophenyl)-5-methylisoxazol-4-yl]carbonyl]-N'-[3-(dimethyla mino)propyl]urea

N-(4-chlorophenyl)-N'-[3-dimethylaminopropyl]urea

N-(3,5-Dichloro-phenyl)-3-(3-dimethylamino-propylamino)-propionamide

[3-(2-Ethyl-6-methyl-pyridin-3-yloxy)-propyl]-dimethyl-amine

8-(3-Dimethylamino-propoxy)-1,3,7-trimethyl-3,7-dihydro-purine-2,6-dione

2-(3-Dimethylamino-propylamino)-isophthalonitrile

Dimethylamino-(3 -methyl-benzo [b]thiophen-2-yl)-propan-1-one (HCl)

N-Benzo[1,3]dioxol-5-ylmethyl-N,N-dimethyl-propane-1,3-diamine

N,N-Dimethyl-N-(5-nitro-quinolin-8-yl)-propane-1,3-diamine

1-(4-Chloro-phenyl)-3-(3-dimethylamino-propyl)-urea

2-Amino-N-(3-dimethylamino-propyl)-benzamide

3-Phenyl-acrylic acid 3-dimethylamino-propyl ester

3,5-Dinitro-benzoic acid 2-dimethylamino-ethyl ester

[4-(4-Bromo-phenyl)-3-(3-dimethylamino-propyl)-3H-thiazol-2-ylidene]-phenyl-amine

3-Methyl-benzofuran-2-carboxylic acid dimethylamino-dimethyl-propyl ester N'-(2-Chloro-4-nitro-phenyl)-N,N-dimethyl-propane-1,3-diamine

[3-(3-Dimethylamino-propyl)-5-(4-nitro-phenyl)-3H-thiazol-2-ylidene]-phenyl-amine

[3-(10,11-Dihydro-dibenzo[a,d]cyclohepten-5-ylidene)-propyl]-dimethyl-amine

2,3-Dimethyl-1H-indole-5-carboxylic acid 2-dimethylamino-ethyl ester

N'-(3,4-Dinitro-5-pyridin-2-yl-thiophen-2-yl)-N,N-dimethyl-propane-1,3-diamine

Cyclooctyl-dithiocarbamic acid 2-dimethylamino-ethyl ester (HCl)

N-(2,6-Difluoro-phenyl)-C-dimethylamino-acetamide

2-Acetylamino-3-(4-chloro-phenyl)-N-(3-dimethylamino-propyl)-acrylamide

N-[2-[5-(4-Bromo-phenyl)-furan-2-yl]-1-(3-dimethylamino-propyl carbamoyl)-vinyl]-4-methyl-benzamide

2,6-Bis-(3-dimethylamino-propylamino)-3-nitro-benzonitrile

N-[2-(2,4-Dichloro-phenoxy)-phenyl]-N'-(3-dimethylamino-propyl)- oxalamide

3,5-Dichloro-N-(3-dimethylamino-propyl)-2,6-dimethoxy-benzamide

2-Dimethylaminomethyl-3,4-dihydro-2H-naphthalen-1-one (HCl)

2-({ 1-[N-(3-Dimethylamino-propyl)-3-trifluoromethyl-phenyl]- methanimidoyl}-amino)-6-fluoro-benzoic acid

2,4-Dichloro-N-(3-dimethylamino-propyl)-N'-hydroxy-benzamidine

3-(3-Methyl-ureido)-4-oxo-3,4-dihydro-quinazoline-2-carboxylic acid

(3-dimethylamino-propyl)-amide

5-Bromo-N-(3-dimethylamino-propyl)-2-hydroxy-benzamide

N-(2,4-Dichloro-phenyl)-6-(2-dimethylamino-ethylsulfanyl)-4- trifluoromethyl-nicotinamide

1-(2,6-Dichloro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid

(2-dimethylamino-ethyl)-amide

3-Amino-4-oxo-3,4-dihydro-quinazoline-2-carboxylic acid

(3-dimethylamino-propyl)-amide

12. Use according to any one of the preceding claims, wherein the medicament is for use as a vasodilator or to inhibit platelet aggregation.

13. Use according to claim 12, wherein the medicament is for use in the

treatment or prevention of a peripheral vascular disease, glaucoma, age- related macular degeneration, preeclampsia, Raynaud's Syndrome, stroke or erectile dysfunction.

14. A method of treating a patient in need of an activator of soluble guanylate cyclase, which method comprises administering to said patient an effective amount of a compound according to any one of claims 1 to 11, or a pharmaceutically acceptable salt thereof.

15. A compound of the formula (I), as defined in any one of claims 1 to 11, or a pharmaceutically acceptable salt thereof, for use in the treatment of the human or animal body by therapy.

16. A compound of the formula (I), as defined in any one of claims 1 to 11, or a pharmaceutically acceptable salt thereof, excluding the following compounds: 2-Benzylsulfanyl-N-(3-dimethylamino-propyl)-benzamide

N-(3-Dimethylamino-propyl)-3-phenoxy-benzamide

1-(4-chlorobenzyl)-3-(2-N,N-dimethylethylamido)-6-pyridone

1-(2,6-dichlorobenzyl)-3-(3-N,N-dimethylpropylamido)-6-pyridone

1-(3-trifluoromethylbenzyl)-3-(2-N,N-dimethylethylamido)-2-pyridone 1-(2,6-dichlorobenzyl)-3-(2-N,N-dimethylethylamido)-2-pyridone

1-(3,4-dichlorobenzyl)-3-(N-[2,N,N-dimethylaminoethylamido])-2-pyridone 1-(2,6-dichlorobenzyl)-3-(N-[2-N,N-dimethylaminoethylamido])-6-pyridone 5-chloro-1-(3,4-dichlorobenzyl)-3-(2-N,N-dimethylaminoethylamido)-6- pyridone

5-chloro-3-(2-N,N-dimethylaminoethylamido)-1-(3-trifluoromethylbenzyl)-6- pyridone

5-chloro-1-(3,4-dichlorobenzyl)-3-N-(2-[N',N'-dimethylaminoethylamido])-2- pyridone

5-chloro-1-(4-chlorobenzyl)-3-N-(2-(N',N'-dimethylamino)ethyl)amido-2- pyridone

5-chloro-1-(3-trifluoromethylbenzyl)-3-N-(2-(N',N'-dimethylamino)ethyl) amido-2-pyridone

1-benzyl-5-chloro-3-N-(2-[N',N'-dimethylamino]ethyl)carboxamido-6-pyridone

5 -chloro-1-(4-chlorobenzyl)-3-N-(2-[N',N'-dimethylamino]ethyl)

carboxamido-6-pyridone

4-(2,4-dichlorobenzoyl)pyrrole-2-N-dimethylaminopropylcarboxamide

4-[(N-[3-(N',N'-dimethylaminopropyl)]carboxamido]-2-phenylthiazole

4-(N-(3-N',N'-dimethylaminopropyl)carboxamido)-2-(4-pyridinyl)thiazole

2-[4-(N-[3-N',N'-dimethylaminopropyl]carboxamido)phenyl-4- (3-trifluoromethylphenyl]thiazole

4-(4-chlorophenyl)-2-(4-[3-N',N'-dimethylaminopropyl]carboxamido)phenyl) thiazole

1-(3,5-bis(trofluoromethyl)benzyl)-3-[N-(2-dimethylaminoethyl)

carboxamido]-2[1H]-pyridone

N-(3-dimethylaminopropyl)-4-(3-chloro-5-trifluoromethyl-2-pyridyloxy) phenylsulfonamide

N 1-[3-(dimethylamino)propyl]-3-[3-chloro-5-(trifluoromethyl)-2-pyridyl] propanamide

3-(N-(2-dimethylaminoethyl)carboxamido]-1-(4-trifluoromethylbenzyl))-2

[1H]-pyridone

1-ethyl-3-(3-dimethylaminopropyl)urea

1-(3-(dimethylamino)-propyl)-3-phenylurea

N 1-[2-(2,4-dichlorophenoxy)phenyl]-N2-[3-(dimethylamino)propyl] ethanediamide

N4-[3-(dimethylamino)propyl]-3-(2,6-dichlorophenyl)-5-methylisoxazole-4-c arboxamide

N-[[3-(2,6-dichlorophenyl)-5-methylisoxazol-4-yl]carbonyl]-N'-[3- (dimethylamino)propyl]urea

N-(4-chlorophenyl)-N'-[3-dimethylaminopropyl]urea

N-(3,5-Dichloro-phenyl)-3-(3-dimethylamino-propylamino)-propionamide [3-(2-Ethyl-6-methyl-pyridin-3-yloxy)-propyl]-dimethyl-amine

8-(3-Dimethylamino-propoxy)-1,3,7-trimethyl-3,7-dihydro-purine-2,6-dione

2-(3-Dimethylamino-propylamino)-isophthalonitrile

Dimethylamino-(3-methyl-benzo[b]thiophen-2-yl)-propan-1-one (HCl) N-Benzo[1,3]dioxol-5-ylmethyl-N,N-dimethyl-propane-1,3-diamine

N,N-Dimethyl-N-(5-nitro-quinolin-8-yl)-propane-1,3-diamine

1-(4-Chloro-phenyl)-3-(3-dimethylamino-propyl)-urea

2-Amino-N-(3-dimethylamino-propyl)-benzamide

3 -Phenyl-acrylic acid 3-dimethylamino-propyl ester

3,5-Dinitro-benzoic acid 2-dimethylamino-ethyl ester

[4-(4-Bromo-phenyl)-3-(3-dimethylamino-propyl)-3H-thiazol-2-ylidene]-phenyl-amine

3-Methyl-benzofuran-2-carboxylic acid dimethylamino-dimethyl-propyl ester

N'-(2-Chloro-4-nitro-phenyl)-N,N-dimethyl-propane-1,3-diamine

[3-(3-Dimethylamino-propyl)-5-(4-nitro-phenyl)-3H-thiazol-2-ylidene]-phenyl-amine

[3-(10,11-Dihydro-dibenzo[a,d]cyclohepten-5-ylidene)-propyl]-dimethyl-amine

2,3-Dimethyl-1H-indole-5-carboxylic acid 2-dimethylamino-ethyl ester N'-(3,4-Dinitro-5-pyridin-2-yl-thiophen-2-yl)-N,N-dimethyl-propane-1,3-diamine

Cyclooctyl-dithiocarbamic acid 2-dimethylamino-ethyl ester (HCl)

N-(2,6-Difluoro-phenyl)-C-dimethylamino-acetamide

2-Acetylamino-3-(4-chloro-phenyl)-N-(3-dimethylamino-propyl)-acrylamide N-[2-[5-(4-Bromo-phenyl)-furan-2-yl]-1-(3-dimethylamino-propylcarbamoyl)-vinyl]-44methyl-benzamide

2,6-Bis-(3-dimethylamino-propylamino)-3-nitro-benzonitrile

N-[2-(2,4-Dichloro-phenoxy)-phenyl]-N'-(3-dimethylamino-propyl)-oxalamide

3,5-Dichloro-N-(3-dimethylamino-propyl)-2,6-dimethoxy-benzamide 2-Dimethylaminomethyl-3,4-dihydro-2H-naphthalen-1-one (HCl) 2-({ 1-[N-(3-Dimethylamino-propyl)-3-trifluoromethyl-phenyl]-methanimidoyl}-amino)-6-fluoro-benzoic acid

2,4-Dichloro-N-(3-dimethylamino-propyl)-N'-hydroxy-benzamidine

3-(3-Methyl-ureido)-4-oxo-3,4-dihydro-quinazoline-2-carboxylic acid (3-dimethylamino-propyl)-amide

5-Bromo-N-(3-dimethylamino-propyl)-2-hydroxy-benzamide N-(2,4-Dichloro-phenyl)-6-(2-dimethylamino-ethylsulfanyl)-4-trifluoromethyl-nicotinamide

1-(2,6-Dichloro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid

(2-dimethylamino-ethyl)-amide

3-Amino-4-oxo-3,4-dihydro-quinazoline-2-carboxylic acid

(3-dimethylamino-propyl)-amide