Search International and National Patent Collections

1. (WO2001032602) DIARYL-ENYNES

Pub. No.:    WO/2001/032602    International Application No.:    PCT/US2000/030074
Publication Date: Fri May 11 01:59:59 CEST 2001 International Filing Date: Thu Nov 02 00:59:59 CET 2000
IPC: A61K 31/21
C07C 229/36
C07C 323/41
C07D 207/325
C07D 307/52
C07D 317/58
C07D 333/20
Applicants: NPS ALLELIX CORP.
Inventors: EGLE, Ian
FREY, Jennifer
ISAAC, Methvin
Title: DIARYL-ENYNES
Abstract:
Provided, among other things, is a compound of Formula (I), wherein, Ar1 and Ar2 are independently selected aryl groups, optionally substituted with up to five substituents independently selected from the group consisting of alkyl, alkoxy, cycloalkyl, cycloalkyloxy, heterocycloalkyl, heterocycloalkyloxy, alkanoyl, thioalkyl, aralkyl, aralkyloxy, aryloxyalkyl, aryloxyalkoxy, cycloalkyl-substituted alkyl, cycloalkyloxy-substituted alkyl, cycloalkyl-substituted alkoxy, cycloalkyloxy-substituted alkoxy, heterocycloalkyl-substituted alkyl, heterocycloalkyloxy-substituted alkyl, heterocycloalkyl-substituted alkoxy, heterocycloalkyloxy-substituted alkoxy, thioaryl, aralkylthio, thioarylalkyl, aralkylthioalkyl, halo, NO2, CF3, CN, OH, alkylenedioxy, SO2NRR', NRR', CO2R (where R and R' are independently selected from the group consisting of H and alkyl), and a second aryl group, which may be substituted as above; R1 is selected from the group consisting of H and alkyl; R2 is selected from the group consisting of H, alkyl and benzyl; R3 is selected from the group consisting of CO2R, CONRR', CONH(OH), COSR, SO2NRR', PO(OR)(OR') and tetrazolyl, wherein R and R' are independently selected from the group consisting of H and alkyl; and a salt, solvate or hydrate thereof.