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1. (WO2001032264) ARYL OLEFINIC AZACYCLIC, AND ARYL ACETYLENIC AZACYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/032264    International Application No.:    PCT/US2000/018292
Publication Date: 10.05.2001 International Filing Date: 30.06.2000
Chapter 2 Demand Filed:    19.04.2001    
IPC:
A61K 31/44 (2006.01), A61K 31/505 (2006.01), C07D 209/02 (2006.01), C07D 213/32 (2006.01), C07D 401/06 (2006.01), C07D 401/14 (2006.01), C07D 453/02 (2006.01), C07D 487/04 (2006.01)
Applicants: TARGACEPT, INC. [US/US]; Post Office Box 1487, Winston-Salem, NC 27102-1487 (US) (For All Designated States Except US).
SCHMITT, Jeffrey, Daniel [US/US]; (US) (For US Only).
DULL, Gary, Maurice [US/US]; (US) (For US Only).
BHATTI, Balwinder, Singh [US/US]; (US) (For US Only)
Inventors: SCHMITT, Jeffrey, Daniel; (US).
DULL, Gary, Maurice; (US).
BHATTI, Balwinder, Singh; (US)
Agent: SAJOVEC, F., Michael; Myers, Bigel, Sibley, & Sajovec, P.A., P.O. Box 37428, Raleigh, NC 27627 (US)
Priority Data:
09/431,700 01.11.1999 US
Title (EN) ARYL OLEFINIC AZACYCLIC, AND ARYL ACETYLENIC AZACYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS
(FR) COMPOSES AZACYCLIQUES OLEFINIQUES D'ARYLE, COMPOSES AZACYCLIQUES ACETYLENIQUES D'ARYLE, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE RECEPTEURS CHOLINERGIQUES NICOTINIQUES
Abstract: front page image
(EN)Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof aryl olefinic azacyclic compounds and aryl acetylenic azacylic compounds, including pyridyl olefinic cycloalkylamines and pyridyl acetylenic cycloalkylamines. Exemplary compounds include (S)-(E)-3-(3-pyrrolidin-2-yl-prop-1-enyl)pyridine, (S)-(E)-3-(2-pyrrolidin-2-ylvinyl)pyridine, 3-(2-pyrrolidin-2-ylethenyl)pyridine, 3-(3-pyrrolidin-2-ylprop-1-enyl)pyridine, 3-(2-(2-azetidinyl)ethenyl)pyridine, 3-(3-(2-azetidinyl) prop-1-enyl)pyridine, 2-(2-(3-pyridyl)ethenyl)-1-azabicyclo[3.3.0]octane, 2-(3-(3-pyridyl)prop-2-enyl)-1-azabicyclo[3.3.0]octane, 3-(2-(3-pyridyl)ethenyl)-2-azabicyclo[2.2.1]heptane, 3-(3-(3-pyridyl)prop-2-enyl)-2-azabicyclo[2.2.1]heptane, 2-(2-(3-pyridyl)ethenyl)-7-azabicyclo[2.2.1]heptane, 2-(3-(3-pyridyl)prop-2-enyl)-7-azabicyclo[2.2.1]heptane, 2-(2-(3-pyridyl)ethenyl)quinuclidine and 2-(3-(3-pyridyl)prop-2-enyl)quinuclidine.
(FR)La présente invention concerne le traitement de patients sensibles à/souffrant d'affections et de troubles, tels que des troubles du système nerveux central, par administration, si le patient le nécessite, de composés azacycliques oléfiniques d'aryle et de composés azacycliques acétyléniques d'aryle, notamment de cycloalkylamines oléfiniques de pyridyle et de cycloalkylamines acétyléniques de pyridyle. Des exemples de composés comprennent (S)-(E)-3-(3-pyrrolidine-2-yle-prop-1-ényle)pyridine, (S)-(E)-3-(2-pyrrolidine-2-ylvinyle)pyridine, 3-(2-pyrrolidine-2-yléthenyle)pyridine, 3-(3-pyrrolidine-2-ylprop-1-ényle)pyridine, 3-(2-(2-azétidinyle)éthényle)pyridine, 3-(3-(2-azétidinyle)prop-1-ényle)pyridine, 2-(2-(3-pyridyle)éthényle)-1-azabicyclo[3.3.0]octane, 2-(3-(3-pyridyle)prop-2-ényle)-1-azabicyclo[3.3.0]octane, 3-(2-(3-pyridyle)éthényle)-2-azabicyclo[2.2.1]heptane, 3-(3-(3-pyridyle)prop-2-ényl)-2-azabicyclo[2.2.1]heptane, 2-(2-(3-pyridyle)éthényle)-7-azabicyclo[2.2.1]heptane, 2-(3-(3-pyridyle)prop-2-ényle)-7-azabicyclo[2.2.1]heptane, 2-(2-(3-pyridyle)éthényle)quinuclidine et 2-(3-(3-pyridyle)prop-2-ényle)quinuclidine.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)