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1. (WO2001032207) METHODS FOR CONFERRING ACTIVE/PASSIVE IMMUNOTHERAPY

Pub. No.:    WO/2001/032207    International Application No.:    PCT/US2000/001112
Publication Date: Fri May 11 01:59:59 CEST 2001 International Filing Date: Thu Jan 20 00:59:59 CET 2000
IPC: A61K 39/385
Applicants: UNITED STATES ARMY MEDICAL RESEARCH AND MATERIEL COMMAND
Inventors: COWAN, Fred, Manley
Title: METHODS FOR CONFERRING ACTIVE/PASSIVE IMMUNOTHERAPY
Abstract:
The Active/Passive Immunotherapy of the present invention combines active immunization to a hapten or immunogen (H/I) and passive immunization with the same H/I conjugated to an antigen binding ligand. The prior immunization to the H/I grants active standing immunity to the H/I whereas the antigen binding ligand grants instant passive binding to the target antigen. The ligand - H/I conjugate acts as a 'sandwich' molecule to provide binding sites to both the target antigen and immune cells to thereby usurp the active standing immunity for the H/I to passive instant immunity for the pathological target antigen. Particular advantages of the present invention include that chemicals as well as peptides can be used as antigen binding ligand, and the full immune repertoire of humoral and/or cellular immunity can be instantly and selectively mobilized and targeted to a pathological antigen. Thus, the present Active/Passive Immunotherapy can provide a generic defense against the myriad of pathological antigens including microbes and other infectious agents, toxins, as well as autoimmune and cancer antigens.