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1. (WO2001032187) INHIBITING FtsZ PROTEIN (DE)POLYMERISATION
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/032187 International Application No.: PCT/NL2000/000809
Publication Date: 10.05.2001 International Filing Date: 06.11.2000
Chapter 2 Demand Filed: 30.05.2001
IPC:
A61K 31/70 (2006.01) ,A61K 31/708 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7042
Compounds having saccharide radicals and heterocyclic rings
7052
having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706
containing six-membered rings with nitrogen as a ring hetero atom
7064
containing condensed or non-condensed pyrimidines
7076
containing purines, e.g. adenosine, adenylic acid
708
having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
Applicants:
DEN BLAAUWEN, Tanneke [NL/NL]; NL (UsOnly)
KOOMEN, Gerrit-Jan [NL/NL]; NL (UsOnly)
NANNINGA, Nanne [NL/NL]; NL (UsOnly)
INSTITUTE FOR MOLECULAR CELL BIOLOGY [NL/NL]; Universiteit Van Amsterdam Kruislaan 316 NL-1098 SM Amsterdam, NL (AllExceptUS)
INSTITUTE OF MOLECULAR CHEMISTRY [NL/NL]; Universiteit Van Amsterdam Nieuwe Achtergracht 129 NL-1018 SW Amsterdam, NL (AllExceptUS)
Inventors:
DEN BLAAUWEN, Tanneke; NL
KOOMEN, Gerrit-Jan; NL
NANNINGA, Nanne; NL
Agent:
PRINS, A., W.; Vereenigde Nieuwe Parklaan 97 NL-2587 BN The Hague, NL
Priority Data:
99203654.104.11.1999EP
Title (EN) INHIBITING FtsZ PROTEIN (DE)POLYMERISATION
(FR) INHIBITION DE LA (DE)POLYMERISATION DE LA PROTEINE FTSZ
Abstract:
(EN) The invention relates to substances with antibiotic activity and methods to treat infections. The invention provides a method to prevent or hamper division or proliferation of a prokaryotic cell or organism comprising inhibiting polymerisation and/or depolymerisation of cell-division protein FtsZ or analogue thereof by contacting said protein with a guanoside triphosphate (GTP) analogue capable of binding to said protein.
(FR) L'invention concerne des substances présentant une activité antibiotique ainsi que des méthodes de traitement d'infections. L'invention concerne une méthode destinée à prévenir ou à entraver la division ou la prolifération d'une cellule ou d'un organisme procaryote consistant à inhiber la polymérisation et/ou la dépolymérisation d'une protéine FtsZ de division cellulaire ou analogue de celle-ci, par mise de ladite protéine en contact avec un analogue de guanoside triphosphate (GTP) capable de se fixer à ladite protéine.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)