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1. (WO2001032179) 8-AZA-BICYCLO[3.2.1]OCTANE NMDA/NR2B ANTAGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/032179 International Application No.: PCT/US2000/029479
Publication Date: 10.05.2001 International Filing Date: 26.10.2000
Chapter 2 Demand Filed: 15.05.2001
IPC:
A61K 31/46 (2006.01) ,C07D 451/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
46
8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
451
Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
02
containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropane; Cyclic acetals thereof
Applicants:
THOMPSON, Wayne [US/US]; US (UsOnly)
CLAREMON, David, A. [US/US]; US (UsOnly)
MUNSON, Peter, M. [US/US]; US (UsOnly)
PHILLIPS, Brian [US/US]; US (UsOnly)
MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue Rahway, NJ 07065-0907, US (AllExceptUS)
Inventors:
THOMPSON, Wayne; US
CLAREMON, David, A.; US
MUNSON, Peter, M.; US
PHILLIPS, Brian; US
Common
Representative:
MERCK & CO., INC.; 126 East Lincoln Avenue Rahway, NJ 07065-0907, US
Priority Data:
60/162,71829.10.1999US
Title (EN) 8-AZA-BICYCLO[3.2.1]OCTANE NMDA/NR2B ANTAGONISTS
(FR) ANTAGONISTES NMDA/NR2B 8-AZA-BICYCLO[3.2.1]OCTANE
Abstract:
(EN) Novel 3-substituted 8-aza-bicyclo[3.2.1]octanes (commonly known as 'tropanes') substituted in the 8-position are effective as NMDA NR2B antagonists useful for relieving pain.
(FR) La présente invention concerne de nouveaux 3-substitué 8-aza-bicyclo[3.2.1]octanes (communément connus sous le nom de « tropanes »), substitués en position 8, qui sont efficaces en tant qu'antagonistes NMDA NR2B, utiles pour soulager la douleur.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)