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1. (WO2001032161) USE OF A HMG-COA REDUCTASE INHIBITOR FOR TREATING AMYLOID BETA PRECURSOR DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/032161 International Application No.: PCT/US2000/041841
Publication Date: 10.05.2001 International Filing Date: 03.11.2000
Chapter 2 Demand Filed: 04.06.2001
IPC:
A61K 9/00 (2006.01) ,A61K 9/20 (2006.01) ,A61K 9/28 (2006.01) ,A61K 31/192 (2006.01) ,A61K 31/22 (2006.01) ,A61K 31/366 (2006.01) ,A61K 31/40 (2006.01) ,A61K 31/401 (2006.01) ,G01N 33/68 (2006.01)
Applicants: ANDRX CORPORATION[US/US]; 4001 S.W. 47th Avenue Fort Lauderdale, FL 33314, US
Inventors: FRIEDHOFF, Lawrence; US
BUXBAUM, Joseph; US
Agent: HERBERT, Toni-Junell ; Shanks & Herbert Suite 306 TransPotomac Plaza 1033 North Fairfax Street Alexandria, VA 22314, US
Priority Data:
60/163,60804.11.1999US
60/219,43520.07.2000US
60/223,98709.08.2000US
Title (EN) USE OF A HMG-COA REDUCTASE INHIBITOR FOR TREATING AMYLOID BETA PRECURSOR DISORDERS
(FR) METHODE DE TRAITEMENT DE TROUBLES LIES AU PRECURSEUR BETA-AMYLOIDE
Abstract: front page image
(EN) Methods for the treatment and prevention of APP processing disorders such as Alzheimer's disease and Down's Syndrome which are based on the administration of an effective amount of a HMG-CoA reductase inhibitor to a mammal are disclosed. Additionally, methods for the treatment and prevention of APP processing disorders such as Alzheimer's disease and Down's Syndrome which are based on the reduction of cellular cholesterol in a mammal are disclosed. These methods reduce the amount of A$g(b) peptides or decrease the formation of A$g(b) peptides or increase the clearance of A$g(b) peptides in a mammal suffering from Alzheimer's disease and Down's Syndrome.
(FR) La présente invention concerne des méthodes de traitements et de prévention des troubles de maturation moléculaire APP (protéine précurseur amyloïde), notamment la maladie d'Alzheimer et le syndrome de Down, consistant à administrer à un mammifère une dose efficace d'un inhibiteur de réductase HMG-CoA. De plus, cette invention concerne des méthodes de traitement et de prévention des troubles de maturation moléculaire APP, notamment la maladie d'Alzheimer et le syndrome de Down, consistant à réduire le taux de cholestérol cellulaire chez le mammifère. Ces méthodes réduisent la quantité de peptides A$g(b), réduisent la formation de peptides A$g(b) ou stimule l'élimination des peptides A$g(b) chez un mammifère souffrant de la maladie d'Alzheimer ou du syndrome de Down.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)