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1. (WO2001032142) CYCLOSPORIN FORMULATION

Pub. No.:    WO/2001/032142    International Application No.:    PCT/GB2000/004143
Publication Date: Fri May 11 01:59:59 CEST 2001 International Filing Date: Sat Oct 28 01:59:59 CEST 2000
IPC: A61K 9/107
A61K 9/14
A61K 9/48
A61K 38/13
Applicants: CIPLA LIMITED
WAIN, Christopher, Paul
HAMIED, Yusuf, Khwaja
NAYAK, Vinay, G.
MALHOTRA, Geena
Inventors: HAMIED, Yusuf, Khwaja
NAYAK, Vinay, G.
MALHOTRA, Geena
Title: CYCLOSPORIN FORMULATION
Abstract:
A pharmaceutical composition in the form of a preconcentrate mixed either with a liquid hydrophilic phase to form a stable oil-in-water microemulsion or with a solid carrier to form a stable, solid blend of carrier and preconcentrate, comprises a) a water-insoluble pharmaceutically active material; b) one or more propylene glycol esters of a fatty acid; c) surfactant; and either d) a hydrophilic phase, wherein component (a) has been wholly directly dissolved in component (b) and component (b) is dispersed as tiny particles in component (d); or e) a solid carrier. The composition is substantially free from ethanol.