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1. (WO2001031325) METHOD FOR SEPARATING A CHEMICAL OR BIOLOGICAL COMPOUND IN A MIXTURE OF SIMILAR COMPOUNDS BY DIFFUSION IN A MEDIUM SUCH AS A GEL

Pub. No.:    WO/2001/031325    International Application No.:    PCT/FR2000/002974
Publication Date: Fri May 04 01:59:59 CEST 2001 International Filing Date: Thu Oct 26 01:59:59 CEST 2000
IPC: G01N 27/447
Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
JULLIEN, Ludovic
LEMARCHAND, Hervé
LEMARCHAND, Annie
Inventors: JULLIEN, Ludovic
LEMARCHAND, Hervé
LEMARCHAND, Annie
Title: METHOD FOR SEPARATING A CHEMICAL OR BIOLOGICAL COMPOUND IN A MIXTURE OF SIMILAR COMPOUNDS BY DIFFUSION IN A MEDIUM SUCH AS A GEL
Abstract:
The invention concerns a method for separating a chemical or biological compound present in a mixture of similar compounds by diffusion in a gel containing a constituent (P) which reacts with the compounds of the mixture in reversible reactions having different kinetic constants from one compound to another. The method consists in applying to the medium (10) for example an electric field (E) varying periodically in time, the period of said field and the concentration of the reactive constituent in the medium (10) being based on the reaction kinetic components of the compounds to be separated to determine the conditions of resonance between said reactions and the applied field, for which the apparent diffusion coefficient of the compound in the medium is maximal.