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1. (WO2001031065) HUMANIZATION OF NON-HUMAN, MAMMALIAN ANTIBODIES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/031065    International Application No.:    PCT/US2000/029026
Publication Date: 03.05.2001 International Filing Date: 20.10.2000
Chapter 2 Demand Filed:    02.05.2001    
IPC:
C07K 16/00 (2006.01)
Applicants: THE SCRIPPS RESEARCH INSTITUTE [US/US]; 10550 North Torrey Pines Road, La Jolla, CA 92037 (US) (For All Designated States Except US).
BARBAS, Carlos, F., III [US/US]; (US) (For US Only).
RADER, Christoph [DE/US]; (US) (For US Only)
Inventors: BARBAS, Carlos, F., III; (US).
RADER, Christoph; (US)
Agent: NORTHRUP, Thomas, E.; The Scripps Research Institute, 10550 North Torrey Pines Road, TPC-8, La Jolla, CA 92037 (US)
Priority Data:
09/425,638 22.10.1999 US
09/543,004 04.04.2000 US
Title (EN) HUMANIZATION OF NON-HUMAN, MAMMALIAN ANTIBODIES
(FR) HUMANISATION D'ANTICORPS DE MAMMIFERES NON HUMAINS
Abstract: front page image
(EN)The present invention provides a process of humanizing non-human, mammalian antibodies. The process combines display technology for expressing libraries of antibody domains and fine tuning of variable domain regions. Humanized antibodies produced by the process are also provided.
(FR)La présente invention concerne un procédé d'humanisation d'anticorps de mammifères non humains. Le procédé combine une technologie de visualisation pour exprimer des bibliothèques de domaines d'anticorps et régler de manière fine des régions de domaines variables. Des anticorps humanisés produits au moyen du procédé selon l'invention sont également décrits.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)