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Machine translation
1. (WO2001031054) METHOD OF SCREENING FOR INHIBITORS OF ASP1
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/031054    International Application No.:    PCT/GB2000/004028
Publication Date: 03.05.2001 International Filing Date: 19.10.2000
Chapter 2 Demand Filed:    17.05.2001    
IPC:
C12N 9/64 (2006.01), G01N 33/68 (2006.01)
Applicants: SMITHKLINE BEECHAM P.L.C. [GB/GB]; Corporate Intellectual Property (CN9.25.1), 980 Great West Road, Brentford, Middlesex, TW8 9GS (GB) (For All Designated States Except US).
SMITHKLINE BEECHAM P.L.C. [GB/GB]; New Horizons Court, Brentford, Middlesex TW8 9EP (GB) (For All Designated States Except US).
CHRISTIE, Gary [GB/GB]; (GB) (For US Only).
HUSSAIN, Ishrut [GB/GB]; (GB) (For US Only).
POWELL, David, Jonathan [IE/GB]; (GB) (For US Only)
Inventors: CHRISTIE, Gary; (GB).
HUSSAIN, Ishrut; (GB).
POWELL, David, Jonathan; (GB)
Agent: VALENTINE, Jill, Barbara; SmithKline Beecham, Corporate Intellectual Property (CN9.25.1), 980 Great West Road, Brentford, Middlesex TW8 9GS (GB).
Peter John Giddings; Smithkline Beecham, Corpoate Intellectual Property_(CN9.25.1), 980 Great West road, Brentford, Middlesex TW8 9GS (GB)
Priority Data:
9925136.5 22.10.1999 GB
Title (EN) METHOD OF SCREENING FOR INHIBITORS OF ASP1
(FR) PROCEDE DE DEPISTAGE DES INHIBITEURS DE ASP1
Abstract: front page image
(EN)A method of screening compounds to identify those compounds which inhibit the Asp 1 mediated cleavage of a polypeptide or protein substrate, the method comprising: providing a reaction system comprising Asp 1 and substrate; and measuring the extent of cleavage of the substrate in the presence of test compound as compared with the extent of cleavage in the absence of test compound, and compounds identified thereby as well as compounds which are inhibitors of Asp 1 modulated APP cleavage and their use in therapy including the treatment or prophylaxis of $g(b) amyloid protein-related disease including AD.
(FR)L'invention concerne un procédé de dépistage de composés servant à identifier ces composés qui inhibent le clivage par Asp 1 d'un polypeptide ou d'un substrat de protéine. Ce procédé comporte les étapes suivantes : la production d'un système de réaction contenant Asp 1 et substrat; la mesure de l'étendue du clivage dudit substrat en présence du composé de test comparée à celle du clivage en l'absence du composé de test, et les composés identifiés de cette manière ainsi que des composés inhibiteurs de clivage APP modulé Asp 1 et leur utilisation thérapeutique comportant le traitement ou la prophylaxie de $g(b) maladies associées à une protéine amyloïde comportant AD.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)