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1. (WO2001031003) CLONING, EXPRESSION AND CHARACTERISATION OF A GENE EXPRESSED IN TUMOUR CELLS AND INVOLVED IN THE REGULATION OF THE IMMUNE RESPONSE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/031003 International Application No.: PCT/FR2000/003032
Publication Date: 03.05.2001 International Filing Date: 30.10.2000
Chapter 2 Demand Filed: 23.05.2001
IPC:
A61K 38/00 (2006.01) ,C07K 14/705 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
Applicants: DELNESTE, Yves[FR/FR]; FR (UsOnly)
MAGISTRELLI, Giovanni[IT/FR]; FR (UsOnly)
JEANNIN, Pascale[FR/FR]; FR (UsOnly)
BONNEFOY, Jean-Yves[FR/FR]; FR (UsOnly)
PIERRE FABRE MEDICAMENT[FR/FR]; 45, place Abel Gance F-92100 Boulogne-Billancourt, FR (AllExceptUS)
Inventors: DELNESTE, Yves; FR
MAGISTRELLI, Giovanni; FR
JEANNIN, Pascale; FR
BONNEFOY, Jean-Yves; FR
Agent: MARTIN, Jean-Jacques ; Cabinet Regimbeau 20, rue de Chazelles F-75847 Paris Cedex 17, FR
Priority Data:
99/1362929.10.1999FR
Title (EN) CLONING, EXPRESSION AND CHARACTERISATION OF A GENE EXPRESSED IN TUMOUR CELLS AND INVOLVED IN THE REGULATION OF THE IMMUNE RESPONSE
(FR) CLONAGE, EXPRESSION ET CARACTERISATION D'UN GENE EXPRIME DANS DES CELLULES TUMORALES ET IMPLIQUE DANS LA REGULATION DE LA REPONSE IMMUNE
Abstract:
(EN) The invention concerns the identification and the characterisation of a novel gene expressed in tumour cells and involved in the regulation of the immune response, the cloning and the characterisation of its cDNA and the corresponding polypeptides. The invention also concerns vectors containing a nucleic acid coding for said gene, cells transformed by said vectors and diagnostic methods and selection methods of a chemical or biological compound capable of directly or indirectly interacting with a nucleic acid or a polypeptide of the invention. The invention further concerns compounds for treating immune pathologies, in particular autoimmune diseases and cancer.
(FR) L'invention concerne l'identification et la caractérisation d'un nouveau gène exprimé dans des cellules tumorales et impliqué dans la régulation de la réponse immune, le clonage et la caractérisation de son ADNc ainsi que les polypeptides correspondants. L'invention concerne également des vecteurs contenant un acide nucléique codant pour ce gène, des cellules transformées par de tels vecteurs ainsi que des méthodes de diagnostic et des méthodes de sélection d'un composé chimique ou biochimique capable d'interagir directement ou indirectement avec un acide nucléique ou polypeptide selon l'invention. L'invention concerne en outre des composés pour le traitement de pathologies immunes, notamment les maladies autoimmunes et le cancer.
Designated States: AU, BR, CA, CN, JP, MX, US, ZA
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: French (FR)
Filing Language: French (FR)