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Machine translation
1. (WO2001030980) METHODS AND COMPOSITIONS FOR ENHANCING DEVELOPMENTAL POTENTIAL OF OOCYTES AND ZYGOTES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2001/030980 International Application No.: PCT/CA2000/001283
Publication Date: 03.05.2001 International Filing Date: 27.10.2000
Chapter 2 Demand Filed: 24.05.2001
IPC:
A01K 67/027 (2006.01) ,A61K 35/00 (2006.01) ,A61K 35/12 (2006.01) ,C12N 15/87 (2006.01)
Applicants: CASPER, Robert, F.[CA/CA]; CA (UsOnly)
ROGERS, Ian[CA/CA]; CA (UsOnly)
TILLY, Jonathan[US/US]; US (UsOnly)
JURISICOVA, Andrea[CA/CA]; CA (UsOnly)
PEREZ, Gloria, I.[CO/US]; US (UsOnly)
MOUNT SINAI HOSPITAL[CA/CA]; Samuel Lunenfeld Research Institute Office of Technology Transfer & Industrial Liaison 600 University Avenue Toronto, Ontario M5G 1X5, CA (AllExceptUS)
THE GENERAL HOSPITAL CORPORATION doing business as MASSACHUSETTS GENERAL HOSPITAL[US/US]; 55 Fruit Street Boston, MA 02113, US (AllExceptUS)
Inventors: CASPER, Robert, F.; CA
ROGERS, Ian; CA
TILLY, Jonathan; US
JURISICOVA, Andrea; CA
PEREZ, Gloria, I.; US
Agent: VAN ZANT, Joan, M. ; Swabey Ogilvy Renault Suite 1600 1981 McGill College Avenue Montreal, Québec H3A 2Y3, CA
Priority Data:
60/161,79727.10.1999US
Title (EN) METHODS AND COMPOSITIONS FOR ENHANCING DEVELOPMENTAL POTENTIAL OF OOCYTES AND ZYGOTES
(FR) PROCEDES ET COMPOSITIONS AMELIORANT LE POTENTIEL DE DEVELOPPEMENT D'OOCYTES ET DE ZYGOTES
Abstract:
(EN) The invention relates to compositions and methods for enhancing the developmental potential of oocytes or zygotes by increasing intracellular levels of replicative mitochondria in the oocytes or zygotes. In one aspect of the invention, the intracellular levels of replicative mitochondria are increased by introducing replicative mitochondria into the oocytes or zygotes. The oocytes may be fertilized to obtain a zygote with increased intracellular levels of replicative mitochondria. The methods and compositions may be used to improve in vitro fertilization and embryo transfer methods, and nuclear transfer techniques.
(FR) L'invention concerne des compositions et des procédés améliorant le potentiel de développement d'oocytes ou de zygotes par augmentation des niveaux intracellulaires de mitochondries réplicatives dans les oocytes ou les zygotes. Selon un aspect de l'invention, les niveaux intracellulaires de mitochondries réplicatives sont augmentés par introduction de mitochondries réplicatives dans les oocytes ou les zygotes. Les oocytes peuvent être fécondés afin d'obtenir un zygote à niveaux intracellulaires augmentés de mitochondries réplicatives. On peut utiliser les procédés et compositions selon l'invention pour améliorer les procédés de fécondation in vitro et de transfert d'embryon, ainsi que les techniques de transfert de matériel nucléaire.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)