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1. (WO2001030853) ANTIBODY AGAINST RAT POSTACROSOME REACTION SPERM AND UTILIZATION THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/030853    International Application No.:    PCT/JP2000/007374
Publication Date: 03.05.2001 International Filing Date: 23.10.2000
Chapter 2 Demand Filed:    21.02.2001    
IPC:
C07K 16/18 (2006.01), G01N 33/577 (2006.01), G01N 33/68 (2006.01)
Applicants: FUSO PHARMACEUTICAL INDUSTRIES, LTD. [JP/JP]; 7-10, Doshomachi 1-chome, Chuo-ku Osaka-shi, Osaka 541-0045 (JP) (For All Designated States Except US).
KUWAHARA, Yoshihiro [JP/JP]; (JP) (For US Only).
HASEGAWA, Michinori [JP/JP]; (JP) (For US Only).
ISAKA, Kiyotsugu [JP/JP]; (JP) (For US Only).
ARAKI, Hiromasa [JP/JP]; (JP) (For US Only)
Inventors: KUWAHARA, Yoshihiro; (JP).
HASEGAWA, Michinori; (JP).
ISAKA, Kiyotsugu; (JP).
ARAKI, Hiromasa; (JP)
Agent: AOYAMA, Tamotsu; Aoyama & Partners IMP Building 3-7, Shiromi 1-chome, Chuo-ku Osaka-shi, Osaka 540-0001 (JP)
Priority Data:
11/304530 26.10.1999 JP
Title (EN) ANTIBODY AGAINST RAT POSTACROSOME REACTION SPERM AND UTILIZATION THEREOF
(FR) ANTICORPS DIRIGE CONTRE LES SPERMATOZOIDES DE LA REACTION POSTACROSOMIQUE DU RAT, ET SON UTILISATION
Abstract: front page image
(EN)An antibody binding specifically to rat postacrosome reaction sperm is produced and hybridomas (FARS-91 and FARS-92 strains) capable of stably proliferating are obtained by fusing mouse spleen cells having a high antibody titer against rat postacrosome reaction sperm with mouse-origin myeloma cells and screening fused cells reacting strongly with rat postacrosome reaction sperm. From these hybridomas, monoclonal antibodies selectively binding to rat postacrosome reaction sperm can be obtained. Thus, a diagnostic method for evaluating rat fertility is presented.
(FR)Selon l'invention, on produit un anticorps se liant spécifiquement aux spermatozoïdes de la réaction postacrosomique du rat et l'on obtient des hybridomes (souches FARS-91 et FARS-92) pouvant proliférer de façon stable par d'une part, la fusion de cellules de rate de souris ayant un titre d'anticorps élevé contre les spermatozoïdes de la réaction postacrosomique du rat avec des cellules de myélomes tirées de la souris et d'autre part, le criblage des cellules fusionnées réagissant fortement avec les spermatozoïdes de la réaction postacrosomique du rat. Il est possible d'obtenir des anticorps monoclonaux se liant sélectivement aux spermatozoïdes de la réaction postacrosomique du rat à partir de ces hybridomes. L'invention porte ainsi sur une méthode diagnostique permettant d'évaluer la fertilité du rat.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)