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1. (WO2001030815) REDOX REVERSIBLE HCV PROTEINS WITH NATIVE-LIKE CONFORMATION

Pub. No.:    WO/2001/030815    International Application No.:    PCT/EP2000/010499
Publication Date: Fri May 04 01:59:59 CEST 2001 International Filing Date: Thu Oct 26 01:59:59 CEST 2000
IPC: A61K 39/00
C07K 14/18
C07K 16/10
Applicants: INNOGENETICS N.V.
BOSMAN, Alfons
DEPLA, Erik
MAERTENS, Geert
Inventors: BOSMAN, Alfons
DEPLA, Erik
MAERTENS, Geert
Title: REDOX REVERSIBLE HCV PROTEINS WITH NATIVE-LIKE CONFORMATION
Abstract:
The present invention relates to HCV proteins in which cysteine residues are reversibly protected during purification. Eventually, this purification procedure results in HCV proteins with biological activity and a native-like protein conformation, which present corresponding epitopes. The present invention pertains also to drug screening methods using these HCV proteins, and diagnostic and therapeutic applications, such as vaccines and drugs.