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1. (WO2001030398) LIGAND CHELATED PARAMAGNETIC MRI CONTRAST AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/030398    International Application No.:    PCT/US2000/041385
Publication Date: 03.05.2001 International Filing Date: 20.10.2000
Chapter 2 Demand Filed:    17.05.2001    
IPC:
A61K 49/14 (2006.01)
Applicants: INSIGHT NEUROIMAGING SYSTEMS, LLC [US/US]; 60 Prescott Street, Worcester, MA 01605 (US)
Inventors: FERRIS, Craig, F.; (US).
CARRAWAY, Robert, E.; (US).
KING, Jean, A.; (US).
DUDYCZ, Lech; (US)
Agent: LAMMERT, Steven, R.; Barnes & Thornburg, 11 South Meridian Street, Indianapolis, IN 46204 (US)
Priority Data:
60/160,933 22.10.1999 US
60/160,990 22.10.1999 US
Title (EN) LIGAND CHELATED PARAMAGNETIC MRI CONTRAST AGENTS
(FR) AGENTS DE CONTRASTE D'IRM PARAMAGNETIQUES A BASE DE LIGAND CHELATE
Abstract: front page image
(EN)Compounds and methods for imaging by MRI tissues having predetermined cellular receptors are described. The imaging agents comprise a receptor-binding ligand covalently bound to a paramagnetic chelate, optionally in combination with compound for enhancing cellular uptake of said agent. Improved MRI is achieved by acquiring MRI signals after period of time sufficient to achieve receptor mediated cellular concentration of the imaging agent.
(FR)L'invention concerne des composés et des procédés servant à former par IRM des images de tissus contenant des récepteurs cellulaires prédéterminés. Les agents d'imagerie comprennent un ligand se liant à des récepteurs, lié de manière covalente à un chélate paramagnétique, éventuellement combiné à un composé renforçant l'interception cellulaire dudit agent. On obtient une IRM améliorée en saisissant les signaux d'IRM après une durée suffisante permettant l'obtention d'une concentration cellulaire de l'agent d'imagerie due aux récepteurs.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)