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1. (WO2001030379) COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING TRANSPLANT REJECTION

Pub. No.:    WO/2001/030379    International Application No.:    PCT/CA2000/001279
Publication Date: Fri May 04 01:59:59 CEST 2001 International Filing Date: Sat Oct 28 01:59:59 CEST 2000
IPC: A61K 38/55
Applicants: LUCAS, Alexandra
MCFADDEN, Grant, D.
ZHONG, Robert
Inventors: LUCAS, Alexandra
MCFADDEN, Grant, D.
ZHONG, Robert
Title: COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING TRANSPLANT REJECTION
Abstract:
Compositions and methods for treating transplant rejection in a mammalian transplant recipient are provided. The method involves administering a therapeutically effective amount of Serp-1, its analogs, and biologically active fragments thereof in combination with an anti-rejection agent, such as cyclosporin, and a pharmaceutically acceptable carrier to a subject in need of such treatment. The compositions and methods are useful for treating acute and chronic allograft and xenograft transplant rejection in mammals.