Search International and National Patent Collections

1. (WO2001030378) A METHOD OF PROPHYLAXIS AND TREATMENT

Pub. No.:    WO/2001/030378    International Application No.:    PCT/AU2000/001299
Publication Date: Fri May 04 01:59:59 CEST 2001 International Filing Date: Sat Oct 21 01:59:59 CEST 2000
IPC: A61K 39/00
C07K 16/28
Applicants: THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH
HARRISON, Leonard, C
HANNINEN, Arno
MARTINEZ, Nathan, R
KRAMER, David
Inventors: HARRISON, Leonard, C
HANNINEN, Arno
MARTINEZ, Nathan, R
KRAMER, David
Title: A METHOD OF PROPHYLAXIS AND TREATMENT
Abstract:
The present invention relates generally to a method of prophylaxis and treatment of autoimmune disease conditions and agents useful for same. In a related embodiment, the present invention contemplates the use of mucosal antigens and/or agents capable of blocking or otherwise delaying cytotoxic T-lymphocyte (CTL) induction and/or maturation to prevent or at least reduce the likelihood or risk of CTL-mediated autoimmune disease. More particularly, the present invention contemplates mucosa-mediated tolerance to protect against or ameliorate the symptoms associated with autoimmune pathology. Even more particularly, the present invention provides a method for preventing clinical insulin-dependent diabetes mellitus (IDDM) or preventing or reducing or ameliorating the effects of clinical IDDM by the aerosol administration of IDDM-associated autoantigens to mucosal surfaces or agents which block CTL induction and/or maturation.