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Machine translation
1. (WO2001030342) FLAVONES AS INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITORS, CYCLOOXYGENASE-2 INHIBITORS AND POTASSIUM CHANNEL ACTIVATORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/030342    International Application No.:    PCT/US2000/041396
Publication Date: 03.05.2001 International Filing Date: 20.10.2000
Chapter 2 Demand Filed:    04.05.2001    
IPC:
A61K 31/122 (2006.01), A61K 31/352 (2006.01), A61K 45/06 (2006.01)
Applicants: BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY [US/US]; 801 North Rutledge Street, Springfield, IL 62794 (US) (For All Designated States Except US).
LEE, Tony, Jer-Fu [US/US]; (US) (For US Only).
CHEN, Yang, Ling, Ling [--/CN]; (TW) (For US Only)
Inventors: LEE, Tony, Jer-Fu; (US).
CHEN, Yang, Ling, Ling; (TW)
Agent: KATZ, Martin, L.; Rockey, Milnamow & Katz, Ltd., Two Prudential Plaza, Suite 4700, 180 North Stetson Avenue, Chicago, IL 60601 (US)
Priority Data:
60/160,612 20.10.1999 US
Title (EN) FLAVONES AS INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITORS, CYCLOOXYGENASE-2 INHIBITORS AND POTASSIUM CHANNEL ACTIVATORS
(FR) UTILISATION DES FLAVONES COMME INHIBITEURS DE L'OXYDE NITRIQUE SYNTHASE INDUCTIBLES, COMME INHIBITEURS DE CYCLOOXYGENASE-2 ET COMME ACTIVATEURS DES CANAUX POTASSIQUES
Abstract: front page image
(EN)The present invention is directed to a method for inhibiting expression of either iNOS or COX-2, or both in mammals using flavone compounds, and pharmaceutically acceptable salts thereof. The present invention is also directed to a method of activating K+ channels in mammals; as well as methods for treating septic shock, for inhibiting expression of angiotensin converting enzyme, for treating or preventing aneurysms and for reducing inflammation and related pathological changes using these compounds. Presently preferred compounds are oroxylin A (5,7-dihydroxy-6-methoxy flavone) and wogonin (5,7-dihydroxy-8-methoxy flavone).
(FR)La présente invention concerne une méthode d'inhibition de l'expression de iNOS ou de COX-2, ou des deux, chez les mammifères en utilisant des composés flavones, et les sels de ceux-ci acceptables sur le plan pharmaceutique. En outre, cette invention concerne un procédé d'activation des canaux K+ chez les mammifères; ainsi que des méthodes de traitement du choc septique, d'inhibition de l'expression de l'enzyme de conversion de l'angiotensine, ainsi que des méthodes thérapeutiques ou prophylactiques contre l'anévrisme, la réduction de l'inflammation et les écarts pathologiques, en utilisant ces composés. Les composés préférés actuellement sont l'oroxyline A (5,7-dihydroxy-6-méthoxy flavone) et la wogonine(5,7-dihydroxy-8-méthoxy flavone).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)