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1. (WO2001030329) COMBINATIONS OF LAMIVUDINE AND ENTECAVIR FOR TREATMENT OF HEPATITIS B VIRUS INFUCTION

Pub. No.:    WO/2001/030329    International Application No.:    PCT/GB2000/004137
Publication Date: Fri May 04 01:59:59 CEST 2001 International Filing Date: Sat Oct 28 01:59:59 CEST 2000
IPC: A61K 31/7068
A61K 31/708
Applicants: GLAXO GROUP LIMITED
BROWN, Nathaniel, A.
CONDREAY, Lynn, D.
GRAY, Douglas, Fraser
RUBIN, Marc
Inventors: BROWN, Nathaniel, A.
CONDREAY, Lynn, D.
GRAY, Douglas, Fraser
RUBIN, Marc
Title: COMBINATIONS OF LAMIVUDINE AND ENTECAVIR FOR TREATMENT OF HEPATITIS B VIRUS INFUCTION
Abstract:
The present invention relates to therapeutic combinations comprising (2R,cis)-4-amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-pyrimidin-2-one (lamivudine) and BMS-200475 which have anti-hepatitis B virus (HBV) activity. The present invention is also concerned with pharmaceutical compositions containing said combinations and their use in the treatment of HBV infections including infections with HBV mutants bearing resistance to nucleoside and/or non-nucleoside inhibitors.