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1. (WO2001030320) BIODEGRADABLE MICROPARTICLES WITH NOVEL ERYTHROPOIETIN STIMULATING PROTEIN

Pub. No.:    WO/2001/030320    International Application No.:    PCT/US2000/029257
Publication Date: Fri May 04 01:59:59 CEST 2001 International Filing Date: Tue Oct 24 01:59:59 CEST 2000
IPC: A61K 9/16
Applicants: AMGEN INC.
Inventors: BURKE, Paul
KLUMB, Lisa
MURPHY, Keith
HERBERGER, John
FRENCH, Donna, L.
Title: BIODEGRADABLE MICROPARTICLES WITH NOVEL ERYTHROPOIETIN STIMULATING PROTEIN
Abstract:
The present invention relates to a composition for the sustained release of biologically active, novel erythropoietin stimulating protein (NESP), and improved methods of forming said composition. The composition comprises polymeric microparticles within which particles of NESP have been dispersed. The improved method utilizes a cosolvent mixture to effect more efficient and rapid removal of residual polymer solvents during any drying process.