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Machine translation
1. (WO2001029246) PROCESS FOR PRODUCING POLYPEPTIDE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/029246    International Application No.:    PCT/JP2000/007288
Publication Date: 26.04.2001 International Filing Date: 19.10.2000
Chapter 2 Demand Filed:    14.05.2001    
IPC:
C07K 16/00 (2006.01)
Applicants: KYOWA HAKKO KOGYO CO., LTD. [JP/JP]; 6-1, Ohtemachi 1-chome, Chiyoda-ku, Tokyo 100-8185 (JP) (For All Designated States Except US).
OGAWA, Tatsuya [JP/JP]; (JP) (For US Only).
KONNO, Yoshinobu [JP/JP]; (JP) (For US Only).
AKASHI, Naohisa [JP/JP]; (JP) (For US Only).
TAKASUGI, Hiroshi [JP/JP]; (JP) (For US Only).
SUGIMOTO, Seiji [JP/JP]; (JP) (For US Only).
YANO, Keiichi [JP/JP]; (JP) (For US Only)
Inventors: OGAWA, Tatsuya; (JP).
KONNO, Yoshinobu; (JP).
AKASHI, Naohisa; (JP).
TAKASUGI, Hiroshi; (JP).
SUGIMOTO, Seiji; (JP).
YANO, Keiichi; (JP)
Priority Data:
11/296267 19.10.1999 JP
Title (EN) PROCESS FOR PRODUCING POLYPEPTIDE
(FR) PROCEDE DE PRODUCTION D'UN POLYPEPTIDE
Abstract: front page image
(EN)A process for producing a desired polypeptide by using rat cells. More particularly speaking, a process for producing the polypeptide which comprises culturing rat cells such as YB2/3HL.P2.G11.16Ag.20 (hereinafter referred to as YB2/0), preferably rat cells obtained by transferring a recombinant DNA containing a DNA encoding the desired polypeptide such as an immunologically functional molecule, in a serum-free medium. Among the desired polypeptides obtained by this method, an antibody obtained by, for example, using transformants of YB2/0 has a high antibody-dependent cytotoxic activity and thus is useful as drugs.
(FR)L'invention concerne un procédé de production d'un polypeptide voulu par l'utilisation de cellules de rat. Plus particulièrement, l'invention concerne un procédé de production du polypeptide consistant en la mise en culture de cellules de rat telles que YB2/3HL.P2.G11.16Ag.20 (ci-après dénommé YB2/0), de préférence des cellules de rat obtenues par transfert d'un ADN recombiné contenant un ADN codant le polypeptide voulu tel qu'une molécule à fonctionnalité immunologique, dans un milieu sans sérum. Parmi les polypeptides voulus obtenus selon cette méthode, un anticorps obtenu, par exemple, à l'aide de transformants de YB2/0 présente une haute activité cytotoxique dépendante des anticorps et est par conséquent utile sous forme de médicaments.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)