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1. (WO2001029199) METHODS FOR USING 22045, A HUMAN CYCLIC NUCLEOTIDE PHOSPHODIESTERASE

Pub. No.:    WO/2001/029199    International Application No.:    PCT/US2000/028806
Publication Date: Apr 26, 2001 International Filing Date: Oct 18, 2000
IPC: A61K 38/00
C12N 9/16
Applicants: MILLENNIUM PHARMACEUTICALS, INC.
KAPELLER-LIBERMANN, Rosana
HUNTER, John, Joseph
WILLIAMSON, Mark
Inventors: KAPELLER-LIBERMANN, Rosana
HUNTER, John, Joseph
WILLIAMSON, Mark
Title: METHODS FOR USING 22045, A HUMAN CYCLIC NUCLEOTIDE PHOSPHODIESTERASE
Abstract:
The present invention relates to methods for using a human cyclic nucleotide phosphodiesterase belonging to the superfamily of mammalian phosphodiesterases. The invention also relates to methods for using polynucleotides encoding the phosphodiesterase. The invention relates to methods using the phosphodiesterase polypetides and polynucleotides as a target for diagnonis and treatment in phosphodiesterase-mediated or -related disorders. The invention further relates to drug-screening methods using the phosphodiesterase polypeptides and polynucleotides to identify agonists and antagonists for diagnonis and treatment. The invention further encompasses agonists and antagonists based on the phosphodiesterase polypeptides and polynucleotides. The invention further relates to agonists and antagonists identified by drug screening methods with the phosphodiesterase polypeptides and polynucleotides as a target.