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1. (WO2001029067) TETRAPEPTIDE STIMULATING FUNCTIONAL ACTIVITY OF NEURONES, PHARMACOLOGICAL AGENT BASED THEREON AND METHOD OF USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/029067    International Application No.:    PCT/RU2000/000218
Publication Date: 26.04.2001 International Filing Date: 25.05.2000
Chapter 2 Demand Filed:    02.05.2001    
IPC:
A61K 38/00 (2006.01), C07K 5/103 (2006.01)
Applicants: SANKT-PETERBURGSKAYA OBSCHESTVENNAYA ORGANIZATSYA 'INSTITUT BIROREGULYATSII I GERONTOLOGII SZO RAMN' [RU/RU]; pr. Dinamo, 3, St.Petersburg, 197110 (RU) (For All Designated States Except US).
KHAVINSON, Vladimir Khatskelevich [RU/RU]; (RU) (For US Only).
MOROZOV, Vyacheslav Grigorievich [RU/RU]; (RU) (For US Only).
MALININ, Vladimir Viktorovich [RU/RU]; (RU) (For US Only).
GRIGORIEV, Evgeny Iosifovich [RU/RU]; (RU) (For US Only)
Inventors: KHAVINSON, Vladimir Khatskelevich; (RU).
MOROZOV, Vyacheslav Grigorievich; (RU).
MALININ, Vladimir Viktorovich; (RU).
GRIGORIEV, Evgeny Iosifovich; (RU)
Agent: SPESIVTSEVA, Irina Jurievna; OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTIJU "KLINIKA INSTITUTA BIOREGULYATSII I GERONTOLOGII", pr. Dinamo, 3, St.Petersburg, 197110 (RU)
Priority Data:
99121778 20.10.1999 RU
Title (EN) TETRAPEPTIDE STIMULATING FUNCTIONAL ACTIVITY OF NEURONES, PHARMACOLOGICAL AGENT BASED THEREON AND METHOD OF USE THEREOF
(FR) TETRAPEPTIDE STIMULANT L'ACTIVITE FONCTIONNELLE DES NEURONES, AGENT PHARMACOLOGIQUE BASE SUR CE TETRAPEPTIDE ET PROCEDE D'UTILISATION CORRESPONDANT
Abstract: front page image
(EN)Tetrapeptide L-alanyl-L-glutamyl-L-asparagyl-L-proline of the general formula L-Ala-L-Glu-Asp-L-Pro is proposed as a biologically active compound stimulating the functional activity of neurones. The application of L-Ala-L-Glu-L-Asp-L-Pro tetrapeptide in medicine is proposed for the preparation of a drug stimulating the functional activity of neurones. There is proposed a pharmacological agent, which contains as its active base an effective amount of L-Ala-L-Glu-L-Asp-L-Pro tetrapeptide or its salts of the amino acid group (acetate, hydrochloride, oxalate) or its slats of carboxyl groups (the salts of sodium, potassium, calcium, lithium, zinc, magnesium, and also the salts of organic and inorganic cations-ammonium, triethylammonium). The agent is proposed for parenteral, intranasal and oral administration. In accordance with the invention, the method of stimulating the functional activity of neurones consists in preventive and/or therapeutic administration to the patient of the pharmacological agent in doses 0.01 to 100 $g(m)g/kg of the body weight at least once a day for a period necessary for attaining a therapeutic effect.
(FR)Selon l'invention, on propose le tétrapeptide L-alanyl-L-glutamyl-L-aspartyl-L-proline ayant la formule générale L-Ala-L-Glu-Asp-L-Pro en tant que composant bioactif qui stimule l'activité fonctionnelle des neurones. On propose d'appliquer le tétrapeptide L-Ala-L-Glu-L-Asp-L-Pro en médecine, pour préparer un médicament stimulant l'activité fonctionnelle des neurones. L'invention propose un agent pharmacologique dont le principe actif est constitué par une quantité efficace du tétrapeptide L-Ala-L-Glu-L-Asp-L-Pro ou de ses sels du groupe d'acides aminés (acétate, hydrochloride, oxalate) ou de ses sels du groupe carboxyle (sels de sodium, potassium, calcium, lithium, zinc, magnésium et sels de cations organiques et inorganiques, à savoir d'ammonium et de triéthylammonium). L'agent est proposé pour l'administration parentérale, intranasale et orale. Selon l'invention, le procédé de stimulation de l'activité fonctionnelle des neurones consiste à administrer au patient de façon préventive et/ou thérapeutique l'agent pharmacologique dans des doses entre 0,01 et 100 $g(m)g/kg du poids corporel au moins une fois par jour, et ce pour atteindre l'effet thérapeutique désiré.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, HR, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)