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1. (WO2001029035) 4-OXOQUINOLIZINE ANTIMICROBIALS HAVING 2-PYRIDONE SKELETONS AS THE PARTIAL STRUCTURE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/029035    International Application No.:    PCT/JP2000/007256
Publication Date: 26.04.2001 International Filing Date: 19.10.2000
Chapter 2 Demand Filed:    05.02.2001    
IPC:
A61K 31/4375 (2006.01), C07D 455/02 (2006.01)
Applicants: SATO PHARMACEUTICAL CO., LTD. [JP/JP]; 5-27, Motoakasaka 1-Chome, Minato-Ku, Tokyo 107-0051 (JP) (For All Designated States Except US).
FUKUMOTO, Ryoichi [JP/JP]; (JP) (For US Only).
KUSAKABE, Hiroyuki [JP/JP]; (JP) (For US Only).
CHU, Chong [CN/JP]; (JP) (For US Only).
KIMURA, Hiroaki [JP/JP]; (JP) (For US Only).
YANAGIHARA, Satoshi [JP/JP]; (JP) (For US Only).
KATO, Masatoshi [JP/JP]; (JP) (For US Only).
HIROSAWA, Chisato [JP/JP]; (JP) (For US Only).
ISHIDUKA, Seiji [JP/JP]; (JP) (For US Only).
SHIZUME, Fusae [JP/JP]; (JP) (For US Only)
Inventors: FUKUMOTO, Ryoichi; (JP).
KUSAKABE, Hiroyuki; (JP).
CHU, Chong; (JP).
KIMURA, Hiroaki; (JP).
YANAGIHARA, Satoshi; (JP).
KATO, Masatoshi; (JP).
HIROSAWA, Chisato; (JP).
ISHIDUKA, Seiji; (JP).
SHIZUME, Fusae; (JP)
Agent: NAKAMURA, Minoru; Room 646, Shin-Tokyo Bldg., 3-1, Marunouchi 3-Chome, Chiyoda-Ku, Tokyo 100-8355 (JP)
Priority Data:
11/296383 19.10.1999 JP
Title (EN) 4-OXOQUINOLIZINE ANTIMICROBIALS HAVING 2-PYRIDONE SKELETONS AS THE PARTIAL STRUCTURE
(FR) ANTIMICROBIENS 4-OXOQUINOLIZINE PRESENTANT DES SQUELETTES 2-PYRIDONE EN TANT QUE STRUCTURE PARTIELLE
Abstract: front page image
(EN)4-Oxoquinolizine antimicrobials having 2-pyridone skeletons as the partial structure and exhibiting potent antimicrobial activities against gram-positive or -negative bacteria or anaerobic bacteria, which are compounds represented by general formula (I) or pharmaceutically acceptable salts thereof, wherein R¿1? is hydrogen or a carboxyl-protecting group; R¿2? is hydrogen, halogeno, lower alkyl, lower alkoxy, or hydroxyl; R¿3? is hydrogen, halogeno, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, hydroxyl, or amino; R¿4? is hydrogen, an amino-protecting group, alkyl, or cycloalkyl; and R¿5? is hydrogen, halogeno, alkyl, alkenyl, cycloalkyl, aryl, alkoxy, alkylthio, hydroxyl, imino, or amino.
(FR)L'invention concerne des antimicrobiens 4-oxoquinolizine ayant des squelettes 2-pyridone comme structure partielle et dotés d'activités antimicrobiennes puissantes contre des bactéries gram positives, gram négatives ou anaérobies, qui sont des composés représentés par la formule générale (I) ou des sels de ceux-ci pharmaceutiquement acceptables. R¿1? représente hydrogène ou un groupe protecteur carboxyle; R¿2? représente hydrogène, halogéno, alkyle inférieur, alcoxy inférieur ou hydroxyle; R¿3? représente hydrogène, halogéno, alkyle inférieur, alcoxy inférieur, alkylthio inférieur, nitro, cyano, hydroxyle ou amino; R¿4? représente hydrogène, un groupe protecteur amino, alkyle ou cycloalkyle; et R¿5? représente hydrogène, halogéno, alkyle, alcényle, cycloalkyle, aryle, alcoxy, alkythio, hydroxyle, imino ou amino.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)