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1. (WO2001029013) PROCESS FOR PREPARING OXAZOLINES FROM TETRAHYDROFURANS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/029013    International Application No.:    PCT/US2000/028815
Publication Date: 26.04.2001 International Filing Date: 19.10.2000
Chapter 2 Demand Filed:    17.05.2001    
IPC:
C07D 263/14 (2006.01), C07D 307/22 (2006.01), C07D 413/06 (2006.01)
Applicants: AGOURON PHARMACEUTICALS, INC. [US/US]; 10350 North Torrey Pines Road, La Jolla, CA 92037 (US)
Inventors: BUSSE, Juliette, Kharsa; (US).
ZOOK, Scott, Edward; (US).
BORER, Bennett, Chaplin; (US)
Agent: MANDRA, Raymond, R.; Fitzpatrick, Cella, Harper & Scinto, 30 Rockefeller Plaza, New York, NY 10112-3801 (US)
Priority Data:
60/160,695 21.10.1999 US
Title (EN) PROCESS FOR PREPARING OXAZOLINES FROM TETRAHYDROFURANS
(FR) PROCEDES DESTINES A LA PREPARATION D'OXAZOLINES A PARTIR DE TETRAHYDROFURANNES
Abstract: front page image
(EN)Methods for the preparation of chemical intermediates in the synthesis of HIV-protease inhibitors related to and including nelfinavir mesylate are disclosed. The method of this invention comprises converting tetrahydrofuran derivatives (II) into oxazolines (I) to provide key reaction intermediates for the preparation of nelfinavir. Also disclosed is a method for the preparation of a chiral amino alcohol from an epoxy-tetrahydrofuran.
(FR)L'invention concerne des procédés destinés à la préparation d'intermédiaires dans la synthèse d'inhibiteurs de la protéase du VIH concernant et comprenant du nelfinavir mesilate. Le procédé de cette invention consiste à transformer des dérivés de tetrahydrofuranne (II) en oxazolines (I) pour obtenir des intermédiaires réactionnels principaux destinés à la préparation de nelfinavir. L'invention concerne également un procédé destiné à la préparation d'un amino-alcool chiral à partir d'un époxy-tétrahydrofuranne.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)