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1. (WO2001028594) TUMOR DETECTION BY IMAGING AND THERAPY OF TUMORS

Pub. No.:    WO/2001/028594    International Application No.:    PCT/IL2000/000668
Publication Date: Apr 26, 2001 International Filing Date: Oct 20, 2000
IPC: A61K 31/00
A61K 49/14
Applicants: FBIT LTD.
TSARFATY, Ilan
SHAHARABANY, Miriam
ABRAMOVITCH, Rinat
KUSHNIR, Tammar
TSARFATY, Galia
ITZCHAK, Yacov
Inventors: TSARFATY, Ilan
SHAHARABANY, Miriam
ABRAMOVITCH, Rinat
KUSHNIR, Tammar
TSARFATY, Galia
ITZCHAK, Yacov
Title: TUMOR DETECTION BY IMAGING AND THERAPY OF TUMORS
Abstract:
A method for detecting or monitoring tumor cells in an individual is provided which is based on routinely used imaging techniques such as magnetic resonance imaging (MRI) and ultrasound techniques. The detection and monitoring of the cells is carried out non-invasively by externally monitoring the level of oxygenation of the cells (measured as BOLD images) and blood flow to the cells (measured by Doppler ultrasound) in a tested tissue of the individual. The method may be used to identify regions in an individual that does not have a pre-known tumorigenic lesion as well as to detect regions having a high probability of comprising cells in a pre-suspected lesion of an individual (which may, for example be a region in where there is a high probability of existence of primary tumor cells based on analysis by routinely used methods). The method comprises use of an agent which administration to the individual or contact with the cells results in enhancement of the oxygen consumption of the cells detectable by the various imaging techniques. The activating agent may, for example, activate the cells by binding to a receptor specifically expressed by the cells. In addition, methods for evaluating the efficacy of anti-tumorigenic treatments based on measuring blood oxygenation levels and blood flow levels to the cells by imaging techniques are also provided. Furthermore, methods for enhancing the efficacy of anti-tumorigenic therapeutic treatments including chemotherapeutical drugs, antibodies, and irradiation treatments are provided which involve administration to the treated individual of an amount of an agent which enhances the oxygenation of the target cells and the blood flow to the target cells in the treated individual. The efficacy of chemical contrast agents used in conjunction with MRI or ultrasound is also enhanced by the provided method.