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1. (WO2001028584) TREATMENT OF RESPIRATORY DISEASES AND INFECTIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/028584    International Application No.:    PCT/AU2000/001254
Publication Date: 26.04.2001 International Filing Date: 16.10.2000
Chapter 2 Demand Filed:    14.05.2001    
IPC:
A61K 35/74 (2006.01), A61K 35/76 (2006.01), A61K 38/16 (2006.01)
Applicants: THE UNIVERSITY OF SYDNEY [AU/AU]; Sydney, NSW 2006 (AU) (For All Designated States Except US).
COOK, David, Ian [AU/AU]; (AU) (For US Only).
KUNZELMANN, Karl [DE/AU]; (AU) (For US Only).
BEESLEY, Alex, Howard [GB/AU]; (AU) (For US Only).
YOUNG, John, Atherton [AU/AU]; (AU) (For US Only).
KING, Nicholas [AU/AU]; (AU) (For US Only).
KARUPIAH, Guna [MY/AU]; (AU) (For US Only)
Inventors: COOK, David, Ian; (AU).
KUNZELMANN, Karl; (AU).
BEESLEY, Alex, Howard; (AU).
YOUNG, John, Atherton; (AU).
KING, Nicholas; (AU).
KARUPIAH, Guna; (AU)
Agent: F B RICE & CO; 139 Rathdowne Street, Carlton, VIC 3053 (AU)
Priority Data:
PQ 3447 15.10.1999 AU
Title (EN) TREATMENT OF RESPIRATORY DISEASES AND INFECTIONS
(FR) TRAITEMENT DE MALADIES ET D'INFECTIONS RESPIRATOIRES
Abstract: front page image
(EN)It has been found that influenza virus, particularly its haemagglutinin protein, causes inhibition of Na+ ion channels in respiratory epithelium. This observation has allowed for the development of novel methods for (i) treating and/or preventing symptoms associated with viral or bacterial infection (e.g. rhinnorhea, otitis media and/or pulmonary oedema), (ii) treating and/or preventing airway mucous obstructions (e.g. such as those associated with cystic fibrosis, asthma, bronchitis or bronchiecstasis), and (iii) treating diseases characterised by overactivity of epithelial Na+ ion channels (e.g. hypertension).
(FR)Il s'est avéré que le virus de la grippe, notamment sa protéine d'hémagglutinine, provoquait l'inhibition des canaux ion Na+ dans l'épithélium des voies respiratoires. Cette observation a permis la mise au point de nouvelles méthodes permettant, (i), de traiter et/ou de prévenir des symptômes associés à une infection virale ou bactérienne (par exemple la rhinorrhée, l'otite moyenne et/ou l'oedème pulmonaire), (ii), de traiter et/ou de prévenir des obstructions des muqueuses des voies aériennes (celles qui sont, par exemple, associées à la mucoviscidose, à l'asthme, à la bronchite ou à la bronchectasie) et, (iii), de traiter des états pathologiques caractérisés par une suractivité des canaux ion Na?+¿ épithéliaux (l'hypertension, par exemple).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)