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1. (WO2001027135) REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO

Pub. No.:    WO/2001/027135    International Application No.:    PCT/US2000/028479
Publication Date: Apr 19, 2001 International Filing Date: Oct 13, 2000
IPC: C07J 69/00
Applicants: JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
Inventors: BEACHY, Philip, A.
Title: REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO
Abstract:
The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function mutations.