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Machine translation
1. (WO2001027126) PROCESS FOR THE PREPARATION OF PHOSPHOROTHIOATE TRIESTERS AND OLIGONUCLEOTIDES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/027126    International Application No.:    PCT/GB2000/003912
Publication Date: 19.04.2001 International Filing Date: 12.10.2000
Chapter 2 Demand Filed:    20.04.2001    
IPC:
C07H 1/00 (2006.01), C07H 21/00 (2006.01)
Applicants: AVECIA LIMITED [GB/GB]; Hexagon House, Blackley, Manchester M9 8ZS (GB) (For All Designated States Except US).
DOUGLAS, Mark, Edward [GB/GB]; (GB) (For US Only).
SCOTT, Kevin, Gerard [GB/GB]; (GB) (For US Only).
MOODY, David, John [GB/GB]; (GB) (For US Only).
MELLOR, Ben James [GB/GB]; (GB) (For US Only)
Inventors: DOUGLAS, Mark, Edward; (GB).
SCOTT, Kevin, Gerard; (GB).
MOODY, David, John; (GB).
MELLOR, Ben James; (GB)
Agent: REVELL, Christopher; Intellectual Property Group, Avecia Limited, Hexagon House, P.O. Box 42, Blackley, Manchester M9 8ZS (GB)
Priority Data:
9924285.1 14.10.1999 GB
Title (EN) PROCESS FOR THE PREPARATION OF PHOSPHOROTHIOATE TRIESTERS AND OLIGONUCLEOTIDES
(FR) PREPARATION DE PHOSPHOROTHIOATE TRIESTERS ET D'OLIGONUCLEOTIDES
Abstract: front page image
(EN)A process for the synthesis of a phosphorothioate triester is provided. The process comprises the reaction, in the presence of a coupling agent, of an H-phosphonate with a substrate comprising a free hydroxy group and bonded to a solid support, thereby forming a supported H-phosphonate diester, and subjecting the H-phosphonate diester to sulphur transfer with a sulphur transfer agent.
(FR)Cette invention concerne un procédé de synthèse d'un phosphorothioate triester. Ce procédé consiste à faire réagir, en présence d'un agent de couplage, un H-phosphonate avec un substrat qui comprend un groupe hydroxy libre et qui est lié à un support solide. Le H-phosphonate diester supporté ainsi obtenu est soumis à un transfert du soufre au moyen d'un agent de transfert de soufre.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)