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Machine translation
1. (WO2001027091) AMINO LACTAM SULFONAMIDES AS INHIBITORS OF A$g(b) PROTEIN PRODUCTION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/027091    International Application No.:    PCT/US2000/027665
Publication Date: 19.04.2001 International Filing Date: 07.10.2000
Chapter 2 Demand Filed:    25.04.2001    
IPC:
C07D 243/10 (2006.01), C07D 243/24 (2006.01), C07D 401/12 (2006.01), C07D 405/12 (2006.01), C07D 409/12 (2006.01), C07D 409/14 (2006.01), C07D 413/12 (2006.01), C07D 417/12 (2006.01)
Applicants: DU PONT PHARMACEUTICALS COMPANY [US/US]; Chestnut Run Plaza, 974 Centre Road, Wilmington, DE 19805 (US)
Inventors: THOMPSON, Lorin, Andrew; (US)
Agent: LARSEN, Scott, K.; Du Pont Pharmaceuticals Company, Legal Patent Records Center, 1007 Market Street, Wilmington, DE 19898 (US)
Priority Data:
60/158,565 08.10.1999 US
Title (EN) AMINO LACTAM SULFONAMIDES AS INHIBITORS OF A$g(b) PROTEIN PRODUCTION
(FR) AMINO SULFONAMIDES DE LACTAME UTILISES COMME INHIBITEURS DE LA PRODUCTION DE PROTEINE A$g(b)
Abstract: front page image
(EN)This invention relates to novel lactams having Formula (I) to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A$g(b)-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to $g(b)-amyloid production such as Alzheimer's disease and Down's Syndrome.
(FR)La présente invention concerne de nouveaux lactames représentés par la formule (I), leurs compositions pharmaceutiques et leurs procédés d'utilisation. Ces nouveaux composés empêchent la transformation de la protéine précurseur amyloïde et, plus spécifiquement empêchent la production de peptide A$g(b), ayant ainsi une action préventive sur la formation des dépôts neurologiques de protéine amyloïde. Cette invention se rapporte plus particulièrement au traitement des troubles neurologiques associés à la production d'amyloïde $g(b), tels que la maladie d'Alzheimer et le syndrome de Down.
Designated States: AU, BR, CA, CN, CZ, EE, HU, IL, IN, JP, KR, LT, LV, MX, NO, NZ, PL, RO, SG, SI, SK, TR, UA, VN, ZA.
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)