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Machine translation
1. (WO2001026684) METHOD FOR TREATING HYPOXIC CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/026684    International Application No.:    PCT/EP2000/010422
Publication Date: 19.04.2001 International Filing Date: 13.10.2000
Chapter 2 Demand Filed:    24.04.2001    
IPC:
A61K 41/00 (2006.01)
Applicants: AVENTIS PHARMA S.A. [FR/FR]; 20, avenue Raymond Aron, F-92160 Antony (FR)
Inventors: MEDLEN, Constance, E.; (ZA)
Agent: LE PENNEC, Magali; Aventis Pharma S.A., Direction Brevets, 20, avenue Raymond Aron, F-92165 Antony Cedex (FR)
Priority Data:
60/159,376 14.10.1999 US
Title (EN) METHOD FOR TREATING HYPOXIC CELLS
(FR) METHODE DE TRAITEMENT DE CELLULES HYPOXIQUES
Abstract: front page image
(EN)The present invention relates to the cytotoxic and radiosensitizing potential of SN-38 (7-ethyl-10-hydroxycamptothecin), a metabolite of CPT-11. SN-38 has been found to be useful for sensitizing hypoxic cells, such as hypoxic cancer cells, to the effects of radiation.
(FR)La présente invention concerne le potentiel cytotoxique et le potentiel de radiosensibilisation de SN-38 (7-éthyl-10-hydroxycamptothécine), un métabolite de CPT-11. Sn-38 est utile pour la sensibilisation de cellules hypoxiques, telles que des cellules cancéreuses hypoxiques, aux effets du rayonnement.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)