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1. (WO2001026654) FAB I INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/026654    International Application No.:    PCT/US2000/027591
Publication Date: 19.04.2001 International Filing Date: 06.10.2000
Chapter 2 Demand Filed:    25.04.2001    
C07D 209/14 (2006.01)
Applicants: SMITHKLINE BEECHAM CORPORATION [US/US]; One Franklin Plaza, Philadelphia, PA 19103 (US) (For All Designated States Except US).
MILLER, William, H. [US/US]; (US) (For US Only).
NEWLANDER, Kenneth, A. [US/US]; (US) (For US Only).
SEEFELD, Mark, A. [US/US]; (US) (For US Only)
Inventors: MILLER, William, H.; (US).
NEWLANDER, Kenneth, A.; (US).
SEEFELD, Mark, A.; (US)
Agent: MCCARTHY, Mary, E.; SmithKline Beecham Corporation, Corporate Intellectual Property, UW2220, 709 Swedeland Road, P.O. Box 1539, King of Prussia, PA 19406-0939 (US)
Priority Data:
60/158,529 08.10.1999 US
Abstract: front page image
(EN)Compounds of formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment bacterial infections wherein: R?1¿ is C¿1-4?alkyl; R?2¿ is C¿1-4?alkyl; R?3¿ is -C¿1-4?alkyl, -C¿0-4?alkyl-Ar or -C¿0-4?alkyl-Het; R?4¿ is -C¿1-4?alkyl, -(CH¿2?)¿1-4?OH, -OC¿1-4?alkyl, -SC¿1-4?alkyl, -N(C¿1-4?alkyl)¿2?, -C¿0-4?alkyl-Ar, -C¿0-?4alkyl-Het, -C¿0-4?alkyl-C¿3-6?cycloalkyl, -CH(OH)-CH¿2?-R* or -(CH¿2?)¿1-3?SO¿2?Ar; R* is C¿1-4?alkyl, Ar or Het; X is H, C¿1-4?alkyl, OR', SR', CN, N(R')¿2?, CH¿2?N(R')¿2?, NO¿2?, CF¿3?, CO¿2?R', CON(R')¿2?, COR', NR'C(O)R', F, Cl, Br, I, or -S(O)¿r?CF¿3?; R' is H, C¿1-6?alkyl or -C¿0-6?alkyl-Ar; and r is 0, 1 or 2; or a pharmaceutically acceptable salt thereof.
(FR)L'invention concerne des composés représentés dans la formule (I) et qui sont des inhibiteurs de Fab I utiles dans le traitement des infections bactériennes. Dans cette formule: R?1¿ représente C¿1-4?alkyle; R?2¿ représente C¿1-4?alkyle; R?3¿ représente -C¿1-4?alkyle, -C¿0-4?alkyle-Ar ou -C¿0-4?alkyle-Het; R?4¿ représente C¿1-4?alkyle, -(CH¿2?)¿1-4?OH, -OC¿1-4?alkyle, -SC¿1-4?alkyle, -N(C¿1-4?alkyle)¿2?, -C¿0-4?alkyle-Ar, -C¿0-?4alkyle-Het, -C¿0-4?alkyle-C¿3-6?cycloalkyle, -CH(OH)-CH¿2?-R* ou -(CH¿2?)¿1-3?SO¿2?Ar; R* représente C¿1-4?alkyle, Ar ou Het; X représente H, C¿1-4?alkyle, OR', SR', CN, N(R')¿2?, CH¿2?N(R')¿2?, NO¿2?, CF¿3?, CO¿2?R', CON(R')¿2?, COR', NR'C(O)R', F, Cl, Br, I, ou -S(O)¿r?CF¿3?; R' représente H, C¿1-6?alkyle ou -C¿0-6?alkyle-Ar; et r représente O, 1 ou 2; ou un sel pharmaceutiquement acceptable de ces derniers.
Designated States: AE, AL, AU, BA, BB, BG, BR, BZ, CA, CN, CZ, DZ, EE, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KP, KR, LC, LK, LR, LT, LV, MA, MG, MK, MN, MX, MZ, NO, NZ, PL, RO, SG, SI, SK, SL, TR, TT, TZ, UA, US, UZ, VN, YU, ZA.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)