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Machine translation
1. (WO2001026644) MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/026644    International Application No.:    PCT/US2000/028579
Publication Date: 19.04.2001 International Filing Date: 13.10.2000
Chapter 2 Demand Filed:    08.05.2001    
IPC:
A61K 31/40 (2006.01), A61K 31/4025 (2006.01)
Applicants: CURIS, INC. [US/US]; 45 Moulton Street, Cambridge, MA 02138 (US)
Inventors: BAXTER, Anthony, David; (GB).
BOYD, Edward, Andrew; (GB).
GUICHERIT, Oivin, M.; (US).
PRICE, Stephen; (GB).
RUBIN, Lee; (US)
Agent: HALSTEAD, David, P.; Foley, Hoag & Eliot, LLP, One Post Office Square, Boston, MA 02109 (US)
Priority Data:
60/159,417 14.10.1999 US
60/196,543 11.04.2000 US
Title (EN) MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO
(FR) MEDIATEURS DE VOIES DE SIGNALISATION HEDGEHOG, COMPOSITIONS ET UTILISATIONS ASSOCIEES
Abstract: front page image
(EN)The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
(FR)La présente invention concerne des procédés et des réactifs permettant d'inhiber des états de croissance aberrants qui résultent de gain de fonction hedgehog, de perte de fonction ptc ou de gain de fonction smoothened. Selon cette invention, la cellule est mise en contact avec un antagoniste d'hedgehog, tel qu'une petite molécule, en quantité suffisante pour permettre un état de croissance aberrant, par exemple pour agoniser une voie ptc normale ou pour antagoniser l'activité smoothened ou hedgehog.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)