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1. (WO2001025465) ADENO-ASSOCIATED VIRUSES AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/025465    International Application No.:    PCT/US2000/027863
Publication Date: 12.04.2001 International Filing Date: 06.10.2000
Chapter 2 Demand Filed:    07.05.2001    
IPC:
A61K 48/00 (2006.01), C12N 15/864 (2006.01)
Applicants: UNIVERSITY OF IOWA RESEARCH FOUNDATION [US/US]; 100 Oakdale Campus, #214 TIC, Iowa City, IA 52242-5000 (US) (For All Designated States Except US).
ENGELHARDT, John, F. [US/US]; (US) (For US Only).
DUAN, Dongsheng [CN/US]; (US) (For US Only).
YAN, Ziyang [CN/US]; (US) (For US Only)
Inventors: ENGELHARDT, John, F.; (US).
DUAN, Dongsheng; (US).
YAN, Ziyang; (US)
Agent: VIKSNINS, Ann, S.; Schwegman, Lundberg, Woessner & Kluth, P.O. Box 2938, Minneapolis, MN 55402 (US)
Priority Data:
60/158,209 07.10.1999 US
Title (EN) ADENO-ASSOCIATED VIRUSES AND USES THEREOF
(FR) VIRUS ADENO-ASSOCIE ET UTILISATIONS CORRESPONDANTES
Abstract: front page image
(EN)The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persistence or abundance of the isolated DNA molecule in a host cell. The invention also provides a composition comprising at least two adeno-associated virus vectors.
(FR)Cette invention se rapporte à une molécule d'ADN isolée et purifiée comprenant au moins un segment d'ADN, une sous-unité biologiquement active ou variante de cette sous-unité, d'un intermédiaire circulaire de virus adéno-associé, ce segment d'ADN assurant une plus grande stabilité, persistance ou abondance épisomique de la molécule d'ADN isolée dans une cellule hôte. Cette invention concerne également une composition comprenant au moins deux vecteurs de virus adéno-associés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)