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1. (WO2001025246) CHROMOGENIC SUBSTRATES OF SIALIDASE OF BACTERIAL, VIRAL, PROTOZOA, AND VERTEBRATE ORIGIN AND METHODS OF MAKING AND USING THE SAME

Pub. No.:    WO/2001/025246    International Application No.:    PCT/US2000/027505
Publication Date: Apr 12, 2001 International Filing Date: Oct 5, 2000
IPC: C07H 15/203
C07H 15/26
C07H 17/02
C07H 17/075
C12Q 1/34
Applicants: IBBEX, INC.
UAB RESEARCH FOUNDATION
Inventors: JOHNSON, Stephen, C.
LUO, Ming
YAN, Shijia
Title: CHROMOGENIC SUBSTRATES OF SIALIDASE OF BACTERIAL, VIRAL, PROTOZOA, AND VERTEBRATE ORIGIN AND METHODS OF MAKING AND USING THE SAME
Abstract:
The current invention relates to the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including human) origin. In particular, this invention provides a novel class of effective compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.