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Pub. No.:    WO/2001/025220    International Application No.:    PCT/US2000/027811
Publication Date: 12.04.2001 International Filing Date: 06.10.2000
Chapter 2 Demand Filed:    05.05.2001    
C07D 251/18 (2006.01), C07D 251/22 (2006.01), C07D 401/04 (2006.01), C07D 401/12 (2006.01), C07D 401/14 (2006.01), C07D 403/04 (2006.01), C07D 403/12 (2006.01), C07D 405/04 (2006.01), C07D 409/04 (2006.01), C07D 417/14 (2006.01)
Applicants: AMGEN INC. [US/US]; One Amgen Center Drive, Thousand Oaks, CA 91320-1799 (US) (For All Designated States Except US).
ARMISTEAD, David, M. [US/US]; (US) (For US Only).
BEMIS, Jean, E. [US/US]; (US) (For US Only).
BUCHANAN, John, L. [US/US]; (US) (For US Only).
DIPIETRO, Lucian, V. [US/US]; (US) (For US Only).
ELBAUM, Daniel [US/US]; (US) (For US Only).
HABGOOD, Gregory, J. [US/US]; (US) (For US Only).
KIM, Joseph, L. [US/US]; (US) (For US Only).
MARSHALL, Teresa, L. [US/US]; (US) (For US Only).
GEUNS-MEYER, Stephanie, D. [US/US]; (US) (For US Only).
NOVAK, Perry, M. [US/US]; (US) (For US Only).
NUNES, Joseph, J. [US/US]; (US) (For US Only).
PATEL, Vinod, F. [US/US]; (US) (For US Only).
TOLEDO-SHERMAN, Leticia, M. [CU/US]; (US) (For US Only).
ZHU, Xiaotian [CN/US]; (US) (For US Only)
Inventors: ARMISTEAD, David, M.; (US).
BEMIS, Jean, E.; (US).
BUCHANAN, John, L.; (US).
DIPIETRO, Lucian, V.; (US).
ELBAUM, Daniel; (US).
HABGOOD, Gregory, J.; (US).
KIM, Joseph, L.; (US).
MARSHALL, Teresa, L.; (US).
GEUNS-MEYER, Stephanie, D.; (US).
NOVAK, Perry, M.; (US).
NUNES, Joseph, J.; (US).
PATEL, Vinod, F.; (US).
TOLEDO-SHERMAN, Leticia, M.; (US).
ZHU, Xiaotian; (US)
Agent: ODRE, Steven, M.; Amgen INC., One Amgen Center Drive, M/S 27-4-A, Thousand Oaks, CA 91320-1799 (US)
Priority Data:
60/158,176 07.10.1999 US
60/166,978 23.11.1999 US
60/170,378 13.12.1999 US
60/183,263 17.02.2000 US
60/215,576 30.06.2000 US
60/219,801 20.07.2000 US
Abstract: front page image
(EN)The invention relates to inhibitors of formula (I) of enzymes that bind to ATP or GTP and/or catalyze phosphoryl transfer, compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising them are useful for treating disease or disease symptoms. The invention also provides for methods of making phosphoryl transferase inhibitor compounds, methods of inhibiting phosphoryl transferase activity, and methods for treating disease or disease symptoms. In formula (I), each R?1¿ and R?2¿ is independently R?3¿; R?8¿; NHR?3¿; NHR?5¿; NHR?6¿; NR?5¿R?5¿; NR?5¿R?6¿; SR?5¿; SR?6¿; SR?3¿; OR?5¿; OR?6¿; OR?3¿; C(O)R?3¿; heterocyclyl optionally substituted with 1-4 independent R?4¿ on each ring; or C1-C10 alkyl substituted with 1-4 independent R?4¿; R?3¿, R?4¿, R?5¿, R?6¿, R?8¿ are as defined in the application.
(FR)Cette invention concerne des inhibiteurs [formule (I)] d'enzymes qui se lient à ATP ou GTP et/ou qui catalysent le transfert de phosphoryle, des compositions renfermant lesdits inhibiteurs, et des méthodes d'utilisation des inhibiteurs et des compositions les renfermant. Ces inhibiteurs et les compositions qui les renferment conviennent pour le traitement de maladies ou de symptômes de maladies. L'invention porte également sur des méthodes de fabrication de composés inhibiteurs de la phosphoryl tranférase, des techniques permettant d'inhiber l'activité de la phosphoryl transférase ainsi que des méthodes de traitement de maladies ou de symptômes de maladies. Dans la formule (I), chaque R?1¿ et R?2¿ est indépendamment R?3¿; R?8¿; NHR?3¿; NHR?5¿; NHR?6¿; NR?5¿R?5¿; NR?5¿R?6¿; SR?5¿; SR?6¿; SR?3¿; OR?5¿; OR?6¿; OR?3¿; C(O)R?3¿; un hétérocyclyle éventuellement substitué par 1-4 R?4¿ indépendant sur chaque noyau; ou un alkyle en C1-C10 substitué par 1-4 R?4¿ indépendant; R?3¿, R?4¿, R?5¿, R?6¿, R?8¿ sont tels que définis dans l'application.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)