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1. (WO2001024826) INREASE OF ENOS ACTIVITY THROUGH ACTIVATION OF THE PI3-KINASE/AKT PATHWAY BY ESTROGENS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/024826    International Application No.:    PCT/US2000/027865
Publication Date: 12.04.2001 International Filing Date: 06.10.2000
Chapter 2 Demand Filed:    07.05.2001    
IPC:
A61K 31/567 (2006.01), A61K 45/06 (2006.01), C12Q 1/48 (2006.01), G01N 33/74 (2006.01)
Applicants: THE BRIGHAM AND WOMEN'S HOSPITAL, INC. [US/US]; 75 Francis Street Boston, MA 02115 (US)
Inventors: LIAO, James, K.; (US).
CHIN, William, W.; (US)
Agent: GATES, Edward, R.; Wolf, Greenfield & Sacks, P.C., 600 Atlantic Avenue, Boston, MA 02210-2206 (US)
Priority Data:
60/158,173 06.10.1999 US
60/158,525 08.10.1999 US
60/163,964 08.11.1999 US
60/163,953 08.11.1999 US
Title (EN) INREASE OF ENOS ACTIVITY THROUGH ACTIVATION OF THE PI3-KINASE/AKT PATHWAY BY ESTROGENS
(FR) COMPOSES ET PROCEDES DE MODULATION DES EFFETS NON TRANSCRIPTIONNELS DES HORMONES STEROIDES
Abstract: front page image
(EN)This invention provides new methods and compounds for controlling the intracellular and physiological effects of steroid hormones, including but not limited to estrogen, through modulation of the interaction of such hormone receptors with phosphatidylinositol-3 kinase. Compounds and methods for controlling the activation of endothelial nitric oxide synthase are also disclosed.
(FR)Cette invention se rapporte à de nouveaux procédés et composés servant à réguler les effets intracellulaires et physiologiques des hormones stéroïdes, telles que notamment l'oestrogène, par modulation de l'interaction de tels récepteurs hormonaux avec la phosphatidylinositol-3 kinase. Cette invention concerne également des composés et des procédés servant à réguler l'activation de l'oxyde nitrique synthase endothéliale.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)